Amphiphilic Bioactive Filler for Acrylic Bone Cement to Enhance Its Cell Adhesion
Amphiphilic Bioactive Filler for Acrylic Bone Cement to Enhance Its Cell Adhesion
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丙烯酸骨水泥用两亲性生物活性填料增强其细胞粘附力
DOI：
10.1166/jbn.2018.2543
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发表时间：
2018
影响因子：
2.9
通讯作者：
Qiu Dong
中科院分区：
文献类型：
--
作者：
Wu Teng;Gao Shan;Cui Yang;Qiao Yan;Zhou Fang;Qiu Dong
提出了生物活性两亲性树莓颗粒（BRP），以解决使用聚甲基丙烯酸甲酯（PMMA）骨水泥时经常发生的骨水泥-骨界面不整合的挑战。BRP被设计成具有不同功能的表面贴片，其中一些是生物活性的以促进与骨的结合，其余是疏水性的以促进与PMMA基质的良好相容性。通过Pickering乳液聚合和表面后修饰，成功地制备了这种功能性颗粒，并发现这种复合骨水泥（BRP-PMMA复合骨水泥）确实能促进骨相关细胞的粘附，而不牺牲传统PMMA骨水泥的任何优点。
Bioactive amphiphilic raspberry particles (BRPs) were proposed to addressing the challenge in cement-bone interface non-integration that was often taking place when poly(methyl methacrylate) (PMMA) bone cements are used. BRPs were designed to have surface patches with different functions, some of which are bioactive to promote bonding to bone and the rest are hydrophobic to promote well compatibility with PMMA matrix. With Pickering emulsion polymerization plus post-modification on surface, such functional particles have been successfully prepared and the composite cements (BRP-PMMA composite cements) were indeed found to promote bone related cell adhesion, while not to sacrifice any of the virtues of the conventional PMMA bone cements.