Molecular biology and epidemiology of Pneumocystis carinii infection in AIDS.
Molecular biology and epidemiology of Pneumocystis carinii infection in AIDS.
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艾滋病卡氏肺囊虫感染的分子生物学和流行病学。
DOI：
10.1097/00002030-199606000-00001
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Walzer,PD
中科院分区：
文献类型：
--
作者：
Stringer,JR;Walzer,PD
艾滋病患者经常发展为卡氏肺孢子虫引起的肺炎。卡氏肺孢子虫肺炎（PCP）是由潜伏菌复活引起的。然而，目前尚不清楚艾滋病患者何时或如何感染卡氏肺孢子虫，最近在了解卡氏肺孢子虫的性质及其与宿主的关系方面取得的进展使潜伏期的作用受到质疑。本文综述了卡氏肺吸虫的分子遗传学研究进展，回顾了近年来关于该菌人际传播的报道，并介绍了该菌在人类和实验动物中的维持情况。应用111分子方法了解AllXS患者卡氏肺孢子虫的来源的进展进行了讨论。
AIDS patients frequently develop pneumonia caused by Pneumocystis carinii. It has been conmonly believed that P carinii pneumonia (PCP) is caused by reactivation of latent organisms. However, it is not known when or how AIDS patients become infected with P carinii, and recent progress in understanding the nature of P carinii and its relationship with its host has called the role of latency into question. This review summarizes recent molecular genetic data on the nature of P carinii, reprises reports suggestive of interpersonal transmission of the microbe, and describes new information pertaining to the maintenance of P carinii in hunnans and laboratory aninnals. Progress in the application of 111olecular approaches to understanding the source of P carinii in AllXS patients is discussed.