Facile preparation of biocompatible polymer microgels with tunable properties and unique functions to solely stabilize high internal phase emulsions
Facile preparation of biocompatible polymer microgels with tunable properties and unique functions to solely stabilize high internal phase emulsions
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轻松制备具有可调节特性和独特功能的生物相容性聚合物微凝胶，可单独稳定高内相乳液
DOI：
10.1016/j.cej.2017.01.052
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发表时间：
2017-05-01
影响因子：
15.1
通讯作者：
Li, Wei
中科院分区：
文献类型：
--
作者：
Hu, Bing;Li, Yunqi;Li, Wei
发现在水溶液中简单地交联壳聚糖（CS）聚集体与京尼平形成生物相容性聚合物微凝胶颗粒，该微凝胶颗粒具有精细可调的尺寸和独特的乳化性质，用于单独稳定高内相乳液（HIPE）。通过改变交联度来控制微凝胶颗粒的尺寸。与其他CS类似物相比，这种微凝胶颗粒在乳化HIPE方面显示出超过100倍的浓度优势。此外，该制备过程避免了以往研究中劳动密集型和使用有毒化学试剂和溶剂的缺点。这样形成的HIPE和大孔聚合物材料具有细胞和可调的孔结构，可以抵抗机械扰动并保持数月。微凝胶颗粒的强乳化性能可归因于交联过程中尺寸和尺寸分布的同时减小和亲油性的增加。该研究为制备性能和功能可调的高分子微凝胶颗粒提供了一种绿色途径，有望用于高分子聚合物和大孔聚合物材料的开发，并有望作为生物相容性载体材料和支架材料得到广泛应用。(C)2017爱思唯尔B.V.保留所有权利。
Simply crosslinking chitosan (CS) aggregates with genipin in an aqueous solution was found to form biocompatible polymer microgel particles with a finely tunable size and unique emulsifying property for solely stabilizing high internal phase emulsions (HIPEs). The size of the microgel particles was controlled by changing the degree of crosslinking. Such microgel particles showed a concentration advantage of more than 100-fold in emulsifying HIPEs compared with other CS analogs. In addition, the fabrication process avoided the drawbacks of labor-intensive and usage of toxic chemical reagents and solvents in other previous studies. The HIPEs and macroporous polymer materials thus formed had a cellular and tunable pore structure that could resist mechanical perturbation and were maintained for months. The strong emulsifying performance of the microgel particles was attributable to a simultaneous reduction in the size and size distribution and increase in lipophilicity during the crosslinking. This study paves the way for a promising green approach to facilely fabricate macromolecule microgel particles with tunable properties and functions for the development of HIPEs and macroporous polymer materials, which are expected to have extensive applications as biocompatible materials for delivery and scaffold design. (C) 2017 Elsevier B.V. All rights reserved.