Extracellular structures in heart muscle.
Extracellular structures in heart muscle.
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心肌的细胞外结构。
DOI：
10.1007/978-1-4757-1287-2_19
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Factor,SM
中科院分区：
文献类型：
--
作者：
Robinson,TF;Cohen-Gould,L;Remily,RM;Capasso,JM;Factor,SM
心肌细胞外基质包含相当多的各种结构。我们已经系统地研究了这些结构的形态，使用固定和显微镜的几种方法。细胞之间的肌内膜连接由胶原蛋白支柱[1]以及弹性蛋白纤维、胶原蛋白纤维和微纤维的组合组成。细胞外基质的其余部分填充有单位胶原纤维、微丝和颗粒的聚阴离子晶格。在这些调查的过程中，我们已经观察到区域的结构连续性的肌膜，从肌内膜胶原支柱Z带。我们还相关的机械阻力拉伸与取向的肌外膜胶原纤维和肌节长度在生活以及固定的大鼠乳头肌。我们的观察表明，细胞外骨骼框架在正常的心脏功能中起着重要的作用。
The extracellular matrix of heart muscle contains a considerable variety of structures. We have systematically studied the morphology of these structures using several methods of fixation and microscopy. Endomysial connections between cells are comprised of struts of collagen [1] as well as combinations of elastin fibers, collagen fibers, and microfibrils. The rest of the extracellular matrix is filled with a polyanionic lattice of unit collagen fibrils, microthreads, and granules. In the course of these investigations, we have observed regions of structural continuity across the sarcolemma, from endomysial collagen struts to Z-bands. We have also correlated the mechanical resistance to stretch with orientation of epimysial collagen fibers and sarcomere lengths in living as well as fixed rat papillary muscles. Our observations suggest that the extracellular skeletal framework plays an important role in normal cardiac function.