Efficacy of fibrin glue on seroma formation after breast surgery.
Efficacy of fibrin glue on seroma formation after breast surgery.
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DOI：
10.1155/2012/643132
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发表时间：
2012
影响因子：
1.9
通讯作者：
Parsafar F
中科院分区：
文献类型：
--
作者：
Miri Bonjar MR;Maghsoudi H;Samnia R;Saleh P;Parsafar F
背景和目标。本研究旨在确定纤维蛋白胶加传统引流管放置与传统引流管放置在预防乳房手术后血清肿方面的有效性。在用于减少血清肿程度和持续时间的方法中，纤维蛋白胶已在许多研究中被提出，但结果存在争议。设计和设置。对随机分为对照组和实验组的受试者进行了一项前瞻性、随机对照研究。方法。收集的数据包括年龄、外科医生、医疗和手术史、合并症、进行的手术、腋窝淋巴结数量、收集的阳性腋窝淋巴结数量、最终病理诊断、癌症分期、住院时间、术后拔除引流管的天数、并发症、血清肿形成的发生率、血清肿消退的时间间隔以及术后就诊次数。结果。对 60 名患者的分析显示相似的匹配组。对照组血清肿形成率为24.1%，纤维蛋白胶组血清肿形成率为16.1%。伤口并发症的发生率相似。结论。虽然与引流放置相比，使用纤维蛋白密封剂导致血清形成率没有显着降低，但较高的成本和繁琐的技术往往表明使用纤维蛋白胶相对于采用所述技术的引流放置没有优势。
Background and Objectives. This study was designed to determine the effectiveness of fibrin glue plus conventional drain placement versus conventional drain placement in the prevention of seromas after breast procedures. Among methods employed to reduce seroma magnitude and duration, fibrin glue has been proposed in numerous studies, with controversial results. Design and Setting. A prospective, randomized, controlled study of subjects who were randomized into control and experimental groups was conducted. Methods. Collected data included age, surgeon, medical and surgical history, comorbidities, procedure performed, number of axillary nodes, number of positive axillary nodes collected, final pathologic diagnosis, cancer stage, hospital stay, postoperative day of drain removal, complications, incidence of seroma formation, interval to seroma resolution, and number of postoperative visits. Results. Analysis of 60 patients showed similarly matched groups. Seroma formation rate was 24.1% in the control group and 16.1% in the fibrin glue group. The rate of wound complications was similar. Conclusions. Although use of fibrin sealant resulted in a nonsignificant decrease in seroma formation rate compared with that of drain placement, the higher cost and cumbersome technique tend to indicate that there is no advantage to using fibrin glue over drain placement with the technique described.