Importance of zwitterionic incorporation into polymethacrylate-based hydrogels for simultaneously improving optical transparency, oxygen permeability, and antifouling properties
Importance of zwitterionic incorporation into polymethacrylate-based hydrogels for simultaneously improving optical transparency, oxygen permeability, and antifouling properties
复制标题
将两性离子掺入聚甲基丙烯酸酯水凝胶对于同时提高光学透明度、透氧性和防污性能的重要性
DOI：
10.1039/c7tb00757d
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发表时间：
2017
影响因子：
7
通讯作者：
Xiao Jian
中科院分区：
文献类型：
--
作者：
Wu Jiang;He Chaochao;He Huacheng;Cheng Chaoqun;Zhu Junyi;Xiao Zecong;Zhang Hongyu;Li Xiaokun;Zheng Jie;Xiao Jian
传统的甲基丙烯酸羟乙酯(HEMA)水凝胶的透光率(OP)和透氧率(DK)与水含量成反比。虽然较高的水含量有利于HEMA基凝胶的透氧性，但由于水诱导的散射中心效应，也会导致较差的光学透明度。在这里，我们提出并证明了将两性离子[2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)氢氧化铵(SBMA)与HEMA水凝胶相结合，可以在高含水率(84%)的水凝胶中实现这两种性能(OP=98%和DK=54.7)，并且这两个值都远远高于纯HEMA水凝胶(OP=2.3%和DK=17.5屏障)。HEMA-SBMA水凝胶通过两性离子SBMA基团之间的静电相互作用和HEMA基团之间的氢键进行交联。SBMA的引入不仅增加了网络中强结合水的数量和质量，而且影响了凝胶的孔结构，这两者都与OP和DK相关。此外，HEMA-SBMA杂化水凝胶在体外表现出良好的防污功能，防止非特异性蛋白质吸附，并在体内植入小鼠体内，表现出生物相容性和血液相容性。HEMA-SBMA水凝胶结合了这些优异的性能(高水分含量、高光学透明度、高透氧性、良好的防污染功能和低异物反应)，使其在基于隐形眼镜的眼科应用中具有极大的前景。这项工作与我们的其他HEMA-CBMA水凝胶一致，提供了一种新的策略来设计杂化亲水-两性离子材料，以改善其感兴趣的多方面性能，而不是传统的亲水-亲水和亲水-疏水材料设计。
Conventional 2-hydroxyethyl methacrylate (HEMA)-based hydrogels have an inverse relationship between optical transparency (OP) and oxygen permeability (Dk) as a function of water content. While the higher water content favors the oxygen permeability of HEMA-based hydrogels, it also causes poor optical transparency due to the water-induced scattering center effect. Here, we propose and demonstrate that the incorporation of zwitterionic [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) with HEMA hydrogels enables the achievement of both properties (OP = 98% and Dk = 54.7) in hydrogels at high water contents of 84%, and both values are much higher than those of pure HEMA hydrogels (OP = 2.3% and Dk = 17.5 barriers). HEMA–SBMA hydrogels are crosslinked by electrostatic interactions between the zwitterionic SBMA groups and hydrogen bonds between the HEMA groups. The introduction of SBMA into HEMA not only increases the quantity and quality of strongly binding water inside the networks, but also affects the porous structure of the gels, both of which are correlated with OP and Dk. Moreover, hybrid HEMA–SBMA hydrogels demonstrate their excellent antifouling function to prevent nonspecific protein adsorption in vitro, as well as their biocompatibility and hemocompatibility when implanted in mice in vivo. A combination of these excellent properties of HEMA–SBMA hydrogels (high water content, high optical transparency, high oxygen permeability, good antifouling function, and low foreign-body reaction) makes them highly promising for contact lens-based ophthalmic applications. This work, in line with our other HEMA–CBMA hydrogels, offers a new strategy to design hybrid hydrophilic-zwitterionic materials for improving their multi-faceted properties of interest, beyond the conventional designs of hydrophilic–hydrophilic and hydrophilic–hydrophobic materials.