Blood brain-barrier disruption of nonionic iodinated contrast medium following coil embolization of a ruptured intracerebral aneurysm.
Blood brain-barrier disruption of nonionic iodinated contrast medium following coil embolization of a ruptured intracerebral aneurysm.
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破裂的脑内动脉瘤线圈栓塞后非离子碘造影剂的血脑屏障破坏。
DOI：
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
N. Hayabuchi
中科院分区：
文献类型：
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作者：
Y. Uchiyama;T. Abe;M. Hirohata;N. Tanaka;K. Kojima;H. Nishimura;A. Norbash;N. Hayabuchi
文献中很少有关于神经介入手术后血脑屏障（BBB）暂时破坏的报道，推测是由非离子放射造影剂（CM）引起的。我们描述了一名因急性蛛网膜下腔出血而就诊的 72 岁男性患者，他接受了破裂的前交通动脉复合体动脉瘤的弹簧圈栓塞治疗。在他后续的CT检查时，在脑脊液（CSF）中发现了大量的碘。由于这一经验，我们测量了另外五名也接受颅内血管内手术的患者脑脊液中的碘浓度。结论是，碘的增加可能是由于血脑屏障的暂时渗漏或崩溃引起的。即使 CM 的总量可能不会过多，注入单个血管区域的不成比例的高浓度可能会造成一组独特的变量，增加 BBB 破坏的风险。
Few reports of temporary disruption of the blood-brain barrier (BBB) following neurointerventional procedures, presumably caused by nonionic radiographic contrast medium (CM), exist in the literature. We described such a case in a 72-year-old man presenting with acute subarachnoid hemorrhage, who underwent coil embolization of a ruptured anterior communicating artery complex aneurysm. At the time of his follow-up CT examination, a large amount of iodine was found in the cerebrospinal fluid (CSF). Because of this experience, the iodine concentration in the CSF of five other patients who also underwent an intracranial endovascular procedure was measured. It was concluded that this increased iodine might have been caused by temporary leakage or breakdown of the BBB. Even if the total amount of CM may not be excessive, the disproportionately high concentration injected into a single vascular territory may pose a unique set of variables increasing the risk of BBB disruption.
造影剂过量后致命的脑水肿。
DOI：
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发表时间：
1986
期刊：
AJNR. American journal of neuroradiology
影响因子：
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作者：
Junck,L;Marshall,WH
通讯作者：
Marshall,WH