Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid and RALDH expression compared to young mice.
Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid and RALDH expression compared to young mice.
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与年轻小鼠相比，老年小鼠 CD4 T 细胞迁移特性的减弱与趋化因子受体表达、对视黄酸的反应和 RALDH 表达的降低相关。
DOI：
10.1080/09168451.2014.910099
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Satoshi Hachimura
中科院分区：
文献类型：
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作者：
Jihyun Park;Takuya Miyakawa;Aya Shiokawa;Haruyo Nakajima-Adachi;Masaru Tanokura;Satoshi Hachimura
衰老导致产生适当免疫反应的能力减弱。用年轻和老年小鼠研究了衰老对CD4+T细胞向趋化因子迁移能力的影响。我们发现，与年轻小鼠相比，老年小鼠抗原刺激的CD4+T细胞向CCL19迁移的能力下降，CCR7的表达水平也降低。在添加视黄酸（RA）后，与年轻小鼠相比，来自老年小鼠的CD4+T细胞显示出降低的CCR9表达水平，并且与年轻小鼠相比，来自老年小鼠的CD4+T细胞向CCL25的迁移能力减弱。我们还观察到，RALDH 2 mRNA的表达减少肠系膜淋巴结树突状细胞从老年小鼠相比，从年轻的小鼠。这些结果表明，在老年小鼠中观察到CD4+T细胞的迁移能力减弱，这与趋化因子受体表达降低相关。此外，由于衰老而减少的产生和对RA的反应可能是肠道免疫系统中这种减弱的迁移能力的原因之一。
Aging results in attenuation of abilities to mount appropriate immune responses. The influence of aging on CD4+T cell migration ability toward chemokines was investigated with young and aged mice. We found functional decline in migration ability toward CCL19 and also decreased CCR7 expression level in antigen-stimulated CD4+T cells from aged mice compared with those from young mice. Upon addition of retinoic acid (RA), CD4+T cells from aged mice showed decreased CCR9 expression level compared to young mice and the migration ability of CD4+T cells from aged mice toward CCL25 was attenuated compared to young mice. We also observed that the expression of RALDH2 mRNA was decreased in mesenteric lymph node dendritic cells from aged mice compared to those from young mice. These results demonstrate that attenuated migration abilities of CD4+T cells were observed in aged mice, which correlated with decreased chemokine receptor expression. Furthermore, the reduced production and response to RA by aging may be one of the causes of such attenuated migration abilities in the intestinal immune system.