A thin film nitinol heart valve.
A thin film nitinol heart valve.
复制标题
薄膜镍钛诺心脏瓣膜。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
G. Carman
中科院分区：
文献类型：
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作者：
L. Stepan;D. Levi;G. Carman
为了制造血栓形成较少且寿命更长的心脏瓣膜，使用薄膜镍钛合金（NiTi）开发了人工心脏瓣膜。使用单个椭圆形薄膜NiTi和由Teflon管和NiTi线制成的支架构建“蝶形”瓣膜。在体外脉动流回路中进行了跨瓣膜的流量测试和压力读数。对未处理和钝化的薄膜镍钛合金进行了生物腐蚀实验。为了确定材料的体内生物相容性，使用覆盖有薄膜NiTi的支架将薄膜镍钛合金植入猪体内。通过瓣膜的流速和压力曲线与通过市售19 mm Perimount Edwards组织瓣膜的流速和压力曲线相当。在Hank溶液中浸泡一个月后，薄膜镍钛合金样品上没有腐蚀迹象。最后，在薄膜镍钛合金植入后2、3、4和6周，从4只猪中取出的器官和组织样品没有出现疾病，薄膜镍钛合金本身也没有血栓形成。虽然长期测试仍然是必要的，但薄膜NiTi可能非常适合用于人工心脏瓣膜。
In order to create a less thrombogenic heart valve with improved longevity, a prosthetic heart valve was developed using thin film nitinol (NiTi). A "butterfly" valve was constructed using a single, elliptical piece of thin film NiTi and a scaffold made from Teflon tubing and NiTi wire. Flow tests and pressure readings across the valve were performed in vitro in a pulsatile flow loop. Bio-corrosion experiments were conducted on untreated and passivated thin film nitinol. To determine the material's in vivo biocompatibility, thin film nitinol was implanted in pigs using stents covered with thin film NiTi. Flow rates and pressure tracings across the valve were comparable to those through a commercially available 19 mm Perimount Edwards tissue valve. No signs of corrosion were present on thin film nitinol samples after immersion in Hank's solution for one month. Finally, organ and tissue samples explanted from four pigs at 2, 3, 4, and 6 weeks after thin film NiTi implantation appeared without disease, and the thin film nitinol itself was without thrombus formation. Although long term testing is still necessary, thin film NiTi may be very well suited for use in artificial heart valves.