The nuclear lamina: Molecular organization and interaction with chromatin
The nuclear lamina: Molecular organization and interaction with chromatin
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DOI：
10.1615/critreveukargeneexpr.v9.i3-4.130
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发表时间：
1999-01-01
影响因子：
1.6
通讯作者：
Gruenbaum, Y
中科院分区：
文献类型：
--
作者：
Goldberg, M;Harel, A;Gruenbaum, Y
核纤层位于内核膜和周围染色质之间。它主要由核纤层蛋白和核纤层相关蛋白组成。核纤层参与核组织、细胞周期调控和分化。因此，其结构和/或功能的损伤导致遗传疾病和细胞凋亡。本文描述了核纤层蛋白的分子组织，它们组装成细丝，它们在核内的分布，以及它们与内核膜的其他蛋白质之间相互作用的复杂网络。最近的研究结果揭示了核纤层和染色质蛋白质之间特异性相互作用的证据。这些包括核纤层蛋白和核心组蛋白、核纤层相关多肽2（LAP 2）和自整合屏障因子（BAF）之间的相互作用以及核纤层蛋白B受体（LBR）和染色体结构域蛋白HP 1之间的相互作用。总之，这些研究归因于核纤层蛋白和核纤层相关蛋白LAP 2和LBR在核组织和核组装中的作用。
The nuclear lamina is located between the inner nuclear membrane and the peripheral chromatin. It is composed mainly of nuclear lamins and lamina-associated proteins. The nuclear lamina is involved in nuclear organization, cell cycle regulation, and differentiation. As such, impairment in its architecture and/or function leads to genetic diseases and apoptosis. This article describes the molecular organization of the nuclear lamins, their assembly into filaments, their distribution within the nucleus, and the complex network of interactions between them and other proteins of the inner nuclear membrane. Recent findings unraveled evidence for specific interactions between proteins of the nuclear lamina and the chromatin. These include interactions between nuclear lamins and core histones, Lamina Associated Polypeptide 2 (LAP2), and the Barrier to Autointegration Factor (BAF) and interactions between lamin B receptor (LBR) and the chromodomain protein HP1. Taken together, these studies attribute a role for both the nuclear lamins and the lamina-associated proteins, LAP2 and LBR, in nuclear organization and nuclear assembly.