High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4
High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4
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DOI：
10.1007/s003350010236
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发表时间：
2001-01-01
期刊：
影响因子：
2.5
通讯作者：
Bachmanov, AA
中科院分区：
文献类型：
--
作者：
Li, X;Inoue, M;Bachmanov, AA
The Sac (saccharin preference) locus affecting mouse behavioral and neural responsiveness to sweeteners has been mapped to distal Chr 4. A putative sweet taste receptor, T1R1, has been recently cloned, and the gene encoding it, Gpr70, has also been mapped to mouse distal Chr 4. To assess Gpr70 as a candidate gene for Snc, we compared the Gpr70 sequences of C57BL/6ByJ and 129P3/J mouse strains with different alleles of Snc. Using Gpr70 sequence variation between the C57BL/6ByJ and 129P3/J strains, we conducted a high-resolution analysis of the chromosomal localization of the Gpr70 and Sac loci in the F-2 hybrids and 129.B6-Sac partially congenic mice originating from these two strains, The Gpr70 gene maps proximal to Sac, which demonstrates that they are different loci.
