Synthesis and characterization of a new thermosensitive chitosan-PEG diblock copolymer
Synthesis and characterization of a new thermosensitive chitosan-PEG diblock copolymer
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DOI：
10.1016/j.carbpol.2008.03.017
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发表时间：
2008-11-04
影响因子：
11.2
通讯作者：
Abdekhodaie, M. J.
中科院分区：
文献类型：
--
作者：
Ganji, F.;Abdekhodaie, M. J.
以过硫酸钾为自由基引发剂，将单甲氧基聚乙二醇大分子单体（PEG）嵌段共聚到壳聚糖主链上，合成了一种新型温敏性水凝胶。该嵌段共聚物表现出从低温下的可注射溶液到体温下的凝胶的热可逆转变。用FT-IR、H-1 NMR、C-13 NMR和DSC技术对合成的共聚物进行了表征。通过溶解性实验比较了壳聚糖共聚前后的水溶性和有机溶性。溶胶-凝胶转变行为进行了研究，使用通过反转方法和粘度测量。壳聚糖-聚乙二醇嵌段共聚物的凝胶化特性使其在生物医学领域具有广阔的应用前景。(c)2008爱思唯尔有限公司保留所有权利。
A novel thermosensitive hydrogel was synthesized by block copolymerization of monomethoxy poly(ethylene glycol) macromere (PEG) onto chitosan backbone, using potassium per sulfate as a free radical initiator. This block copolymer exhibits a thermoreversible transition from an injectable solution at low temperature to a gel at body temperature. Synthesized copolymers were characterized using FT-IR, H-1 NMR, C-13 NMR, and DSC techniques. Solubility test was performed to compare water and organo-solubility of chitosan before and after copolymerization. Sol-gel transition behavior was investigated using the via inversion method and viscosity measurements. The gelation behavior makes the chitosan-PEG block copolymers more promising and attractive materials for biomedical applications. (c) 2008 Elsevier Ltd. All rights reserved.