A continuum approach to modelling cell-cell adhesion
A continuum approach to modelling cell-cell adhesion
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DOI：
10.1016/j.jtbi.2006.05.030
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发表时间：
2006-11-07
影响因子：
2
通讯作者：
Sherratt, Jonathan A.
中科院分区：
文献类型：
--
作者：
Armstrong, Nicola J.;Painter, Kevin J.;Sherratt, Jonathan A.
细胞通过细胞粘附分子在细胞表面的结合而彼此粘附。这个过程被称为细胞-细胞粘附，在生物学的许多领域都很重要，包括早期胚胎发育，组织稳态和肿瘤生长。在本文中，我们开发了一个新的连续的数学模型，这一现象考虑的运动细胞的粘附力通过绑定产生的。我们证明，我们的模型预测的聚集行为的解离的粘附细胞群体。此外，当模型扩展到代表多个群体之间的相互作用，我们证明，它是能够复制实验观察到的不同类型的细胞分选行为。由此产生的图案形成是模型中自种群和交叉种群粘合剂结合的相对强度的直接结果。虽然细胞分选行为以前已经用离散方法捕获，但直到现在，还没有用完全连续的模型观察到。(c)2006爱思唯尔有限公司保留所有权利。
Cells adhere to each other through the binding of cell adhesion molecules at the cell surface. This process, known as cell-cell adhesion, is fundamental in many areas of biology, including early embryo development, tissue homeostasis and tumour growth. In this paper we develop a new continuous mathematical model of this phenomenon by considering the movement of cells in response to the adhesive forces generated through binding. We demonstrate that our model predicts the aggregation behaviour of a disassociated adhesive cell population. Further, when the model is extended to represent the interactions between multiple populations, we demonstrate that it is capable of replicating the different types of cell sorting behaviour observed experimentally. The resulting pattern formation is a direct consequence of the relative strengths of self-population and cross-population adhesive bonds in the model. While cell sorting behaviour has been captured previously with discrete approaches, it has not, until now, been observed with a fully continuous model. (c) 2006 Elsevier Ltd. All rights reserved.