Venous Thromboembolism and Arterial Complications
Venous Thromboembolism and Arterial Complications
复制标题
静脉血栓栓塞和动脉并发症
DOI：
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发表时间：
2012
影响因子：
3.2
通讯作者：
R. Pesavento
中科院分区：
文献类型：
--
作者：
P. Prandoni;C. Piovella;R. Pesavento
摘要越来越多的证据表明静脉和动脉血栓形成之间存在联系。这两种血管并发症有几个共同的危险因素，如年龄、肥胖、吸烟、糖尿病、高血压、高血脂和代谢综合征。此外，还有许多导致静脉和动脉血栓形成的情况，如抗磷脂抗体综合征、高同型半胱氨酸血症、恶性肿瘤、感染和激素治疗的使用。最后，最近的几项研究一致表明，静脉血栓栓塞患者发生动脉血栓并发症的风险高于匹配的对照个体。因此，我们推测这两种血管并发症是由负责激活动脉和静脉系统中的凝血和炎症通路的生物刺激同时触发的。未来的研究需要澄清这种关联的性质，评估其程度，并评估其对临床实践的影响。
Abstract An increasing body of evidence suggests the likelihood of a link between venous and arterial thrombosis. The two vascular complications share several risk factors, such as age, obesity, smoking, diabetes mellitus, blood hypertension, hypertriglyceridemia, and metabolic syndrome. Moreover, there are many examples of conditions accounting for both venous and arterial thrombosis, such as the antiphospholipid antibody syndrome, hyperhomocysteinemia, malignancies, infections, and the use of hormonal treatment. Finally, several recent studies have consistently shown that patients with venous thromboembolism are at a higher risk of arterial thrombotic complications than matched control individuals. We, therefore, speculate the two vascular complications are simultaneously triggered by biological stimuli responsible for activating coagulation and inflammatory pathways in both the arterial and the venous system. Future studies are needed to clarify the nature of this association, to assess its extent, and to evaluate its implications for clinical practice.
影响因子：
37.8
作者：
Folsom, AR;Wu, KK;Chambless, LE
通讯作者：
Chambless, LE
DOI：
10.1056/nejmoa0900241
发表时间：
2009-04-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Glynn RJ;Danielson E;Fonseca FA;Genest J;Gotto AM Jr;Kastelein JJ;Koenig W;Libby P;Lorenzatti AJ;MacFadyen JG;Nordestgaard BG;Shepherd J;Willerson JT;Ridker PM
通讯作者：
Ridker PM