Data on the effects of N-cadherin perturbation on the expression of type II cadherin proteins and major signaling pathways.
Data on the effects of N-cadherin perturbation on the expression of type II cadherin proteins and major signaling pathways.
复制标题
N-钙粘蛋白扰动对 II 型钙粘蛋白表达和主要信号通路影响的数据。
DOI：
10.1016/j.dib.2018.08.029
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发表时间：
2018
期刊：
影响因子：
1.2
通讯作者：
Rogers,CrystalD
中科院分区：
文献类型：
--
作者：
Rogers,CrystalD
这篇文章包含与题为“N-钙粘蛋白和E-钙粘蛋白之间的连环蛋白依赖性平衡控制神经外胚层细胞命运选择”（Rogers et.例如，2018）[1]。这里提供的数据包括（1）使用识别I型钙粘蛋白的抗体的邻位连接测定（N-钙粘蛋白和E-钙粘蛋白）与抗II型钙粘蛋白的抗体共孵育（2）用全长N-钙粘蛋白和N-钙粘蛋白阻断吗啉代电穿孔后钙粘蛋白-6 B和钙粘蛋白-7的表达;（3）N-cadherin蛋白缺失后鸡胚WNT、Notch和TGF-β信号报告子和效应子的表达。
This article contains data related to the research article entitled, “A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices” (Rogers et. al., 2018) [1]. The data presented here include (1) proximity ligation assays using antibodies that recognize type I cadherins (N-cadherin and E-cadherin) co-incubated with antibodies against type II cadherins (Cadherin-6B and Cadherin-11) to test heterotypic interactions in vivo; (2) expression of Cadherin-6B and Cadherin-7 after electroporation with full length N-cadherin and N-cadherin translation-blocking morpholino; and (3) expression of WNT, Notch and TGF-β signaling reporters and effectors after loss of N-cadherin protein in chicken embryos.