Etiology of parkinsonism in a Brazilian movement disorders clinic
Etiology of parkinsonism in a Brazilian movement disorders clinic
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DOI：
10.1590/s0004-282x1998000200001
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发表时间：
1998-06-01
影响因子：
1.4
通讯作者：
Silva, GA
中科院分区：
文献类型：
--
作者：
Cardoso, F;Camargos, ST;Silva, GA
目的：探讨帕金森综合征（PA）的病因是否存在地域差异。背景：在北方半球的运动障碍门诊中，72%的PA患者被诊断为帕金森病（PD）。其他地区的数据不详。研究方法：我们回顾了从1993年7月到1995年10月在米纳斯吉拉斯的联邦大学运动障碍诊所就诊的所有PA患者的病历。PA被诊断为至少存在以下两个：静止性震颤，运动迟缓，僵硬，姿势不稳定的不同病因诊断标准的基础上，结果：在研究期间，PA被确认在338名受试者。临床诊断为PD（68.9%）、药物性PA（DIP）（13.3%）、血管性PA（4.7%）、进行性核上性麻痹（PSP）（2%）、多系统萎缩（MSA）（1.8%）、其他（9.7%）。与DIP相关的药物以桂利嗪、氟哌啶醇和氟桂利嗪最常见。结论：与其他研究相似，PD约占PA患者的70%。然而，我们的结果与以前的系列之间存在差异。DIP在目前的系列中更为常见。这可能是由于在我们的环境中更自由地使用抗多巴胺能药物，特别是钙通道阻滞剂。在我们的研究中，MSA和PSP的频率较低可能反映了随访时间较短，因为许多最初诊断为PD的患者后来被发现患有帕金森综合征。
Objective: The aim of the present study is to investigate whether there are geographic differences in the etiology of parkinsonism (PA). Background: 72% of patients with PA evaluated at movement disorders clinics in the Northern Hemisphere are diagnosed with Parkinson's disease (PD). Data regarding other regions are not available. Methods: We reviewed the charts of all patients with PA seen at the Federal University of Minas Gerais Movement Disorders Clinic from July 1993 through October 1995. PA was diagnosed by the presence of at least two of the following: rest tremor, bradykinesia, rigidity, and postural instability The different etiologies were diagnosed based on standard clinical criteria Results: During the period of the study, PA was recognized in 338 subjects. The following clinical diagnoses were made: PD (68.9%), drug-induced PA (DIP) (13.3%), vascular PA (4.7%), Progressive supranuclear palsy (PSP) (2%), multiple system atrophy (MSA) (1.8%), others (9.7%). Cinnarizine, haloperidol and flunarizine were the commonest drugs related to DIP. Conclusions: Similarly to other studies, PD accounts for about 70% of PA patients. However, there are differences between our results and previous series. DIP is much more common in the present series. This may be accounted for a more liberal use of antidopaminergic drugs in our environment, especially Calcium channel blockers. The lower frequency of MSA and PSP in our study may reflect a short follow-up, since many patients initially diagnosed with PD later are found to have Parkinson-plus syndromes.