Molecular Engineering of Luminogens for High-Integrity Imaging of Hydrogen Polysulfides via Activatable Aggregation-Induced Dual-Color Fluorescence
Molecular Engineering of Luminogens for High-Integrity Imaging of Hydrogen Polysulfides via Activatable Aggregation-Induced Dual-Color Fluorescence
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DOI：
10.1021/acsnano.3c08767
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发表时间：
2023-10-27
期刊：
影响因子：
17.1
通讯作者：
Zhao，Chunchang
中科院分区：
文献类型：
--
作者：
Zheng，Zhecha;Gao，Jinzhu;Zhao，Chunchang
了解与H2Sn相关而不是由H2S介导的生物事件具有重要意义，但由于缺乏高完整性的成像工具，仍有待解决。本文报道了一种利用发光体分子工程技术制备的H2S对H2S的化学选择性探针。基于我们对具有高选择性的H2Sn可激活探针的搜索，我们制备了水溶性和生物相容性的纳米探针。这种设计的纳米探针显示出罕见的聚集诱导的双色荧光响应H2Sn，照亮了明亮的发射波长分别为588和750 nm。利用这种可激活的双色荧光，成功地实现了细胞内H2Sn的高完整性鉴定。因此，我们的方法H2Sn-激活的荧光探针可以提供有价值的洞察询问H2Sn介导的生物事件。
Understanding biological events associated with H2Snrather than mediated by H2S is of great significance but remains to be solved due to a lack of high-integrity imaging tools. In this study, we report a chemoselective probe for H2Snover H2S through the molecular engineering of luminogens. Based on our search for H2Sn-activatable probes with high selectivity, we fabricate water-soluble and biocompatible nanoprobes. Such a designed nanoprobe shows rare aggregation-induced dual-color fluorescence responses to H2Sn, lighting up bright emissions at 588 and 750 nm, respectively. By use of this activatable dual-color fluorescence, high-integrity identification of intracellular H2Snwas successfully realized. Thus, our approach to H2Sn-activated multicolor fluorescent probes could provide valuable insight into interrogating H2Sn-mediated biological events.