Neocortical glial cell numbers in human brains
Neocortical glial cell numbers in human brains
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DOI：
10.1016/j.neurobiolaging.2007.04.013
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发表时间：
2008-11-01
影响因子：
4.2
通讯作者：
Pakkenberg, B.
中科院分区：
文献类型：
--
作者：
Pelvig, D. P.;Pakkenberg, H.;Pakkenberg, B.
对31例正常人死后的大脑新皮层进行了立体细胞计数，其中18例为女性（平均年龄65岁，范围18-93岁），13例为男性（平均年龄57岁，范围19-87岁）。细胞分别分化为星形胶质细胞、少突胶质细胞、小胶质细胞和神经元，并分别对四个脑叶进行计数。研究表明，不同的神经胶质细胞亚群随着年龄的增长表现不同；少突胶质细胞的数量在成年期显著减少27%，且与神经元总数有很强的相关性，而星形胶质细胞的总数在一生中是恒定的；最后，男性的新皮质胶质细胞数量比女性高28%，新皮质神经元数量比女性高19%。女性新皮质神经元和胶质细胞总数为493亿个，男性为652亿个，差异为24%，具有较高的生物学变异。这些数字可以作为定量研究人类新皮层的参考值。(C) 2007爱思唯尔公司版权所有。
Stereological cell counting was applied to post-mortem neocortices of human brains from 31 normal individuals, age 18-93 years, 18 females (average age 65 years, range 18-93) and 13 males (average age 57 years, range 19-87). The cells were differentiated in astrocytes, oligodendrocytes, microglia and neurons and counting were done in each of the four lobes.The study showed that the different subpopulations of glial cells behave differently as a function of age; the number of oligodendrocytes showed a significant 27% decrease over adult life and a strong correlation to the total number of neurons while the total astrocyte number is constant through life; finally males have a 28% higher number of neocortical glial cells and a 19% higher neocortical neuron number than females. The overall total number of neocortical neurons and glial cells was 49.3 billion in females and 65.2 billion in males, a difference of 24% with a high biological variance. These numbers can serve as reference values in quantitative studies of the human neocortex. (C) 2007 Elsevier Inc. All rights reserved.