High-throughput in vivo genetic and drug screening using femtosecond laser nano-surgery, and microfluidics.
High-throughput in vivo genetic and drug screening using femtosecond laser nano-surgery, and microfluidics.
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使用飞秒激光纳米手术和微流体进行高通量体内遗传和药物筛选。
DOI：
10.1109/iembs.2008.4649743
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Yanik,MehmetFatih
中科院分区：
文献类型：
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作者：
Rohde,Christopher;Gilleland,Cody;Samara,Chrysanthi;Zeng,Fei;Yanik,MehmetFatih
我们展示了微流体装置和成像技术，用于清醒小动物（秀丽隐杆线虫）的高速固定、细胞分辨率成像和飞秒激光显微手术，用于神经变性和再生的高通量体内遗传和药物筛选。
We demonstrate microfluidic devices and imaging technologies for high-speed immobilization, cellular resolution imaging, and femtosecond laser micro-surgery of awake small-animals (C. elegans) for high-throughput in vivo genetic and drug screens on neural degeneration and regeneration.