The definition of tuberculosis infection based on the spectrum of tuberculosis disease.
The definition of tuberculosis infection based on the spectrum of tuberculosis disease.
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DOI：
10.1183/20734735.0079-2021
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Goletti D
中科院分区：
文献类型：
--
作者：
Migliori GB;Ong CWM;Petrone L;D'Ambrosio L;Centis R;Goletti D
潜伏性结核感染是传统上用来表示结核病 (TB) 感染的术语。该术语用于定义“通过结核菌素皮试 (TST) 或干扰素-γ 释放测定 (IGRA) 等测试，对结核分枝杆菌抗原刺激产生持续免疫反应的状态，而无临床活动性结核病”。最近的证据表明，从结核感染到结核病的范围要复杂得多，包括教学报告中未感染个体、结核感染、初期结核、无体征/症状的亚临床结核、具有无法识别体征/症状的亚临床结核以及具有体征/症状的结核病的“连续体”。最近的证据表明，亚临床结核病是结核分枝杆菌传播的重要原因。本评论描述了上述不同阶段及其关系。报告还总结了结核感染预防、诊断和治疗的新进展及其对公共卫生和政策的影响。描述“结核感染”定义的演变，并从理论上描述结核感染和疾病之间存在的阶段的连续性。讨论预防、诊断和治疗结核感染的推荐方法。从结核感染到疾病的演变现在被描述为“连续过程”。了解这一点对于理解结核感染的预防、诊断和治疗方面的最新进展非常重要。 https://bit.ly/3jauRKA
Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define “a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or an interferon-γ release assay (IGRA) without clinically active TB”. Recent evidence indicates that the spectrum from TB infection to TB disease is much more complex, including a “continuum” of situations didactically reported as uninfected individual, TB infection, incipient TB, subclinical TB without signs/symptoms, subclinical TB with unrecognised signs/symptoms, and TB disease with signs/symptoms. Recent evidence suggests that subclinical TB is responsible for important M. tuberculosis transmission. This review describes the different stages described above and their relationships. It also summarises the new developments in prevention, diagnosis and treatment of TB infection as well as their public health and policy implications. To describe the evolution of the definition of “tuberculosis infection” and didactically describe the continuum of stages existing between TB infection and disease. To discuss the recommended approaches to prevent, diagnose and treat TB infection. The evolution from TB infection to disease is now described as a “continuum process”. Understanding of this is important to appreciate what is new on prevention, diagnosis and treatment of TB infection. https://bit.ly/3jauRKA