Developmental Patterning by Mechanical Signals in Arabidopsis
Developmental Patterning by Mechanical Signals in Arabidopsis
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DOI：
10.1126/science.1165594
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发表时间：
2008-12-12
期刊：
影响因子：
56.9
通讯作者：
Traas, Jan
中科院分区：
文献类型：
--
作者：
Hamant, Olivier;Heisler, Marcus G.;Traas, Jan
发育生物学的一个中心问题是机械力是否以及如何作为细胞行为的线索，从而调节形态发生。我们发现拟南芥茎尖的形态发生依赖于微管骨架，而微管骨架又受机械应力的调控。实验和建模的组合表明，包含组织形态、应力模式和微管介导的细胞特性的反馈回路足以解释在表皮细胞中观察到的微管阵列的协调模式以及顶端形态发生的模式。
A central question in developmental biology is whether and how mechanical forces serve as cues for cellular behavior and thereby regulate morphogenesis. We found that morphogenesis at the Arabidopsis shoot apex depends on the microtubule cytoskeleton, which in turn is regulated by mechanical stress. A combination of experiments and modeling shows that a feedback loop encompassing tissue morphology, stress patterns, and microtubule- mediated cellular properties is sufficient to account for the coordinated patterns of microtubule arrays observed in epidermal cells, as well as for patterns of apical morphogenesis.