Screening for radiation sensitizers of Drosophila checkpoint mutants.
Screening for radiation sensitizers of Drosophila checkpoint mutants.
复制标题
筛选果蝇检查点突变体的辐射增敏剂。
DOI：
10.1007/978-1-61779-273-1_9
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Su,TinTin
中科院分区：
文献类型：
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作者：
Gladstone,Mara;Su,TinTin
抗癌治疗主要包括放射、手术和化疗治疗。虽然单一的治疗模式可以有效地治疗某些类型的癌症，但没有一种可以治愈。多模式治疗，联合使用两种或多种药物（例如，放射和化学疗法一起）显示出更有效治疗癌症的潜力。接下来的挑战是确定有效的治疗组合。在这一章中，我们描述了使用果蝇作为一个整体动物在体内模型，筛选小分子，有效地联合收割机与电离辐射杀死检查点突变体优先于野生型。野生型和检查点突变体的区别使用具有鉴定分子的潜力，所述分子在与辐射组合时以基因型特异性方式起作用以根除检查点突变组织，同时保留野生型组织。
Anti-cancer therapy is largely comprised of radiation, surgery, and chemotherapy treatments. Although a single mode of therapy can be effective in treating certain types of cancer, none presents a cure. Multi-modal therapy, the use of two or more agents in combination (e.g., radiation and chemotherapy together), shows potential for a more effective treatment of cancer. The challenge then is identifying effective therapy combinations. In this chapter, we describe the use of Drosophila as a whole animal in vivo model to screen for small molecules that effectively combine with ionizing radiation to kill checkpoint mutants preferentially over wild-type. The differential use of wild-type and checkpoint mutants has the potential to identify molecules that act in a genotype-specific manner to eradicate checkpoint mutant tissues when combined with radiation, while sparing wild-type tissues.