Peptides as key components in the design of non‐viral vectors for gene delivery
Peptides as key components in the design of non‐viral vectors for gene delivery
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DOI：
10.1002/pep2.24189
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发表时间：
2020-09
期刊：
影响因子：
2.4
通讯作者：
Joseph Thomas;Kamia Punia;J. Montclare
中科院分区：
文献类型：
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作者：
Joseph Thomas;Kamia Punia;J. Montclare
临床成功的基因递送依赖于使用基于病毒或非病毒的载体来包装和保护治疗性核酸。这些载体还必须能够在货物进入细胞后指挥其命运，以确保核酸的功能，并实现预期的结果。与病毒载体相比，非病毒载体具有结合不同材料类型的优势，如脂质、聚合物和肽，以调整整体安全性和有效性。肽在基因传递载体中的作用尤其强大，因为它们能够通过引入新的生化功能来提高基因传递效率。这篇综述将讨论在非病毒基因传递载体中使用多肽作为核心设计成分。多肽组分对运载工具整体功能的贡献将被强调，重点是多肽作为唯一的运载工具组分或多肽与脂质或聚合物的复杂组装。
Successful clinical implementation of gene delivery relies on the use of viral or non‐viral based vectors to package and protect the therapeutic nucleic acid. These vehicles must also be able to direct the fate of the cargo once it has entered the cell to ensure that the nucleic acid is functional, and the desired outcome is achieved. Compared to viral vectors, non‐viral vectors have the advantage of incorporating different material types such as lipids, polymers, and peptides to tune overall safety and efficacy. Peptides are especially powerful when used in gene delivery vectors as they are able to increase gene delivery efficacy by introducing new biochemical functionality. This review will discuss the use of peptides as central design components in non‐viral gene delivery vectors. The contribution of the peptide component to the overall functionality of the delivery vehicle will be highlighted, with a focus on peptides as the only vehicle component or peptides in complex assemblies with lipids or polymers.