Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue.
Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue.
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DOI：
10.1007/s10439-010-0002-x
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发表时间：
2010-08
影响因子：
3.8
通讯作者：
Oomens, C. W. J.
中科院分区：
文献类型：
--
作者：
Loerakker, S.;Stekelenburg, A.;Strijkers, G. J.;Rijpkema, J. J. M.;Baaijens, F. P. T.;Bader, D. L.;Nicolay, K.;Oomens, C. W. J.
关键词：
覆盖骨隆起的软组织的机械负荷可导致骨骼肌损伤，最终导致称为深部组织损伤的严重压疮。最近，通过实验-数值方法表明，一旦超过变形阈值，局部组织变形就会导致组织损伤。在本研究中，研究了负荷暴露时间和间歇负荷解除对形变诱导的肌肉损伤的影响。数据显示，2小时的加载时间比10分钟的加载时间造成的损害更大。在2小时的负荷期内，间歇性的2分钟的负荷减轻对骨骼肌损伤的演变影响很小。此外，还发现了损伤的局部变形门槛值，该门槛值对于本研究中应用的每种加载方式都是相似的。对于短时间的负荷，这些结果表明局部组织变形决定了肌肉损伤是否会发展，暴露时间影响组织损伤的量。暂时的负荷解除在减少形变引起的损伤方面效果不佳，但在较长的负荷时间内仍可能影响缺血诱导的损伤的发展。
Mechanical loading of soft tissues covering bony prominences can cause skeletal muscle damage, ultimately resulting in a severe pressure ulcer termed deep tissue injury. Recently, by means of an experimental-numerical approach, it was shown that local tissue deformations cause tissue damage once a deformation threshold is exceeded. In the present study, the effects of load exposure time and intermittent load relief on the development of deformation-induced muscle damage were investigated. The data showed that a 2 h loading period caused more damage than 10 min loading. Intermittent load reliefs of 2 min during a 2 h loading period had minimal effect on the evolution of skeletal muscle damage. In addition, a local deformation threshold for damage was found, which was similar for each of the loading regimes applied in this study. For short loading periods, these results imply that local tissue deformations determine whether muscle damage will develop and the exposure time influences the amount of tissue damage. Temporary load reliefs were inefficient in reducing deformation-induced damage, but may still influence the development of ischemia-induced damage during longer loading periods.
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