A lymph node interdigitating reticulum cell sarcoma.
A lymph node interdigitating reticulum cell sarcoma.
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淋巴结叉指网状细胞肉瘤。
DOI：
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发表时间：
1994
影响因子：
4.6
通讯作者：
N. Ifrah
中科院分区：
文献类型：
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作者：
M. Rousselet;S. François;A. Croué;M. Maigre;J. Saint;N. Ifrah
一名 20 岁女性因双侧颈部、锁骨上和纵隔淋巴结肿大就诊。淋巴结活检标本显示大的多形性细胞弥漫性恶性增殖。超微结构特征和抗原表型（HLA-DR、CD68、α1-抗胰凝乳蛋白酶和 S100 蛋白的表达以及 CD11c、CD15 和花生凝集素的不稳定反应性）与指状网状细胞的衍生一致。尽管进行了自体骨髓移植和局部放疗的强化联合化疗，患者的疾病最初部位还是复发了。对之前 12 份叉指网状细胞肉瘤报告的回顾表明，大多数罕见肿瘤都具有侵袭性，并且对经典的强化化疗方案没有反应。
A 20-year-old woman presented with bilateral cervical, supraclavicular, and mediastinal lymphadenopathy. A nodal biopsy specimen showed a diffuse malignant proliferation of large pleomorphic cells. The ultrastructural features and the antigen phenotype (expression of HLA-DR, CD68, alpha 1-antichymotrypsin, and S100 protein and inconstant reactivity for CD11c, CD15, and peanut agglutinin) were consistent with a derivation from interdigitating reticulum cells. Despite intensive combination chemotherapy with autologous bone marrow transplantation and local irradiation, the patient relapsed in the initial sites of the disease. A review of 12 previous reports of interdigitating reticulum cell sarcomas showed that most of these rare tumors behaved aggressively and were unresponsive to classic intensive chemotherapeutic regimens.