From bad to worse: when lung cancer complicates idiopathic pulmonary fibrosis.
From bad to worse: when lung cancer complicates idiopathic pulmonary fibrosis.
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从不良到更糟：当肺癌使特发性肺纤维化复杂化时。
DOI：
10.1002/path.5027
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发表时间：
2018-04
期刊：
影响因子：
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通讯作者：
Kass DJ
中科院分区：
文献类型：
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作者：
Strock SB;Alder JK;Kass DJ
特发性肺纤维化患者发生肺癌的风险显著增加。这种疾病的发病率和死亡率是相当大的，不幸的是，目前很少有数据来帮助指导临床医生在其诊断和治疗。在最近一期的杂志中，Hwang等人介绍了在分子水平上评估特发性肺纤维化患者肺癌的首批研究之一。它们证明了细胞周期调节因子的变异，已知这些变异在恶性转化中很重要，也可能在特发性肺纤维化的发病机制中很重要。进一步了解肺癌和特发性肺纤维化之间的致病重叠可能有助于为未来这两种疾病的特定诊断模式和靶向治疗指明方向。
Patients with idiopathic pulmonary fibrosis have a significantly increased risk for the development of lung cancer. The morbidity and mortality of this disease combination are substantial, and, unfortunately, there are currently few data to help guide clinicians in its diagnosis and treatment. In a recent issue of this journal, Hwang et al presented one of the first studies to evaluate lung cancer in patients with idiopathic pulmonary fibrosis at the molecular level. They demonstrate variants in regulators of the cell cycle, which are known to be important in malignant transformation and may also be important in the pathogenesis of idiopathic pulmonary fibrosis. Further understanding of the pathogenic overlap between lung cancer and idiopathic pulmonary fibrosis could help point the direction to specific diagnostic modalities and targeted treatment of both conditions in the future.