Incidence of and potential risk factors for gallstone disease in a general population sample
Incidence of and potential risk factors for gallstone disease in a general population sample
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DOI：
10.1002/bjs.6687
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发表时间：
2009-11-01
影响因子：
9.6
通讯作者：
Borch, K.
中科院分区：
文献类型：
--
作者：
Halldestam, I.;Kullman, E.;Borch, K.
背景资料：一些流行病学研究已发表，但有几个报告之间的关系胆囊结石的发病率，pathologyandriskfactors.Methods：621随机选择的个人年龄在35-85岁的一般人群中谁是以前筛选，超声检查，发现没有胆囊结石，503（81.0%）进行了重新检查后，最小间隔5年。在基线和重新检查，遗传胆石病进行了探讨和身体质量指数，消化系统症状，包括腹痛，生活质量，饮酒和吸烟习惯，使用非甾体抗炎药和雌激素，奇偶校验和血脂水平weredecorded.Results：四十二（8.3%）的503名受试者发展结石。受试者共随访3025.8人-年，新发胆结石的发病率为1.39/100人-年。仅在随访时间和基线血浆低密度脂蛋白胆固醇水平方面发现与胆结石形成呈正相关。每周饮酒量呈负相关胆结石development.Conclusion：胆结石的发病率在这一人群中为1.39每100人年。胆结石的发生与随访时间和低密度脂蛋白胆固醇水平有关，与饮酒量呈负相关。
Background: Several epidemiological studies have been published, but there are few reports on relations between gallstone incidence, symptomatology and risk factors.Methods: Of 621 randomly selected individuals aged 35-85 years in a general population who been screened previously, with ultrasonography and found to have no gallbladder stones, 503 (81.0 per cent) were re-examined after a minimum interval of 5 years. At baseline and re-examination, heredity for gallstone disease was explored and body mass index, digestive symptoms including abdominal pain, quality of life, alcohol and smoking habits, use of non-steroidal anti-inflammatory drugs and oestrogen, parity and blood lipid levels were recorded.Results: Forty-two (8.3 per cent) of the 503 subjects developed stones. Subjects were followed for a total of 3025.8 person-years, yielding an incidence for newly developed gallstones of 1.39 per 100 person-years. A positive association for gallstone development,was found only for length of follow-up and plasma low-density lipoprotein-cholesterol levels at baseline. Weekly alcohol consumption was inversely related to gallstone development.Conclusion: The incidence of gallstones in this population was 1.39 per 100 person-years. Gallstone development was related to length of follow-up and LDL-cholesterol levels, and inversely related to alcohol consumption.