Esophageal cancer related gene-4 inhibits the migration and proliferation of oral squamous cell carcinoma through BC200 lncRNA/MMP-9 and-13 signaling pathway
Esophageal cancer related gene-4 inhibits the migration and proliferation of oral squamous cell carcinoma through BC200 lncRNA/MMP-9 and-13 signaling pathway
复制标题
食管癌相关基因4通过BC200 lncRNA/MMP-9和-13信号通路抑制口腔鳞癌的迁移和增殖
DOI：
10.1016/j.cellsig.2019.05.012
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发表时间：
2019-10-01
影响因子：
4.8
通讯作者：
Dang, Xitong
中科院分区：
文献类型：
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作者：
Huang, Wenjun;Zhou, Rui;Dang, Xitong
食管癌相关基因4（ECRG 4）抑制口腔鳞癌恶性表型。然而，其分子机制仍有待探索。以舌癌细胞系TCA 8113为模型，我们发现ECRG 4的强制表达下调了BC 200长非编码RNA（lncRNA）和基质金属蛋白酶（MMP-9和MMP-13）的表达。BC 200 lncRNA的恢复挽救了ECRG 4介导的MMP-9和MMP-13的下调。此外，Ecrg 4过表达抑制细胞增殖和迁移，这是取消了在TCA 8113细胞中的BC 200 lncRNA的强制表达。我们的研究结果表明，ECRG 4抑制TCA 8113细胞的恶性表型最有可能通过抑制BC 200 lncRNA/MMPs信号通路，合理化BC 200 lncRNA可能是一个潜在的目标，口腔鳞状细胞癌（OSCC）的治疗。
Esophageal cancer related gene-4 (ECRG4) inhibits the malignant phenotype of oral squamous cell carcinoma. However, the molecular mechanisms remain to be explored. Using the tongue carcinoma cell line, TCA8113 as a cell model, we showed that forced expression of ECRG4 down-regulated the expression of the BC200 long non coding RNA (lncRNA) and matrix metalloproteinases (MMP-9 and MMP-13). Restoration of BC200 lncRNA rescued ECRG4-mediated down-regulation of MMP-9 and-13. Furthermore, over-expression of Ecrg4 inhibited cell proliferation and migration, which was abolished by forced expression of BC200 lncRNA in TCA8113 cells. Our results indicate that ECRG4 inhibits the malignant phenotype of TCA8113 cells most likely through suppression of BC200 lneRNA/MMPs signaling pathway, rationalizing that BC200 lncRNA may be a potential target for oral squamous cell carcinoma (OSCC) therapy.