Association between statin use and physical function among community-dwelling older Japanese adults
Association between statin use and physical function among community-dwelling older Japanese adults
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DOI：
10.1111/ggi.13228
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发表时间：
2018-04-01
影响因子：
3.3
通讯作者：
Obuchi, Shuichi
中科院分区：
文献类型：
--
作者：
Kawai, Hisashi;Ihara, Kazushige;Obuchi, Shuichi
他汀类药物相关肌肉症状（SAMS）是他汀类药物的肌肉相关副作用，但他汀类药物使用与社区老年人身体功能之间的关联尚不清楚。本研究的目的是研究他汀类药物的使用和身体功能之间的关联在社区居住的日本老年人考虑他汀类药物相关的肌肉symptoms.MethodsThe参与者的危险因素是1022社区居住的老年人年龄在65-88岁，谁参加了全面的健康检查，从2013年至2015年。通过使用他们的药物笔记本中的数据来验证参与者（381名男性和559名女性）中他汀类药物的使用。使用t检验分析了他汀类药物使用（使用者和非使用者）和身体功能（握力、膝关节伸展扭矩、正常和最大步态速度、计时起身测试、单腿站立、股四头肌肌肉厚度和回声强度）之间的差异。多元回归分析也进行了检查他汀类药物的使用和身体功能之间的关联。ResultsA共93名男性（24.4%）和154名女性（27.5%）是他汀类药物用户。他汀类药物使用者的握力、正常步态速度和单腿站立位显著低于非使用者。在多元回归分析，同时控制他汀类药物相关的肌肉症状的危险因素，包括年龄，性别，体重指数和药物的数量，没有独立的关联，他汀类药物的使用和身体功能的减少之间，observed.ConclusionsStatin的使用与身体功能的下降在社区居住的老年日本成年人。Geriatr Gerontol Int 2018; 18：623-630.
AimStatin-associated muscle symptoms (SAMS) are the muscle-related side-effects of statins, but the association between statin use and physical function among community-dwelling older adults is unclear. The objective of the present study was to examine the association between statin use and physical function among community-dwelling older Japanese adults by considering the risk factors of statin-associated muscle symptoms.MethodsThe participants were 1022 community-dwelling older adults aged 65-88 years, who participated in comprehensive health checkups from 2013 to 2015. Statin use in the participants (381 men and 559 women) was verified by using data from their medicine notebooks. The differences between statin use (users and non-users) and physical functions (grip strength, knee extension torque, normal and maximum gait speed, Timed Up & Go test, one-legged stance, quadriceps muscle thickness and echo intensity) were analyzed using the t-test. Multiple regression analyses were also carried out to examine the association between statin use and physical function.ResultsA total of 93 men (24.4%) and 154 women (27.5%) were statin users. Grip strength, normal gait speed and one-legged stance declined significantly in statin users compared with the non-users. In multiple regression analysis while controlling for the risk factors of statin-associated muscle symptoms, including age, sex, body mass index and number of medicines, no independent association, between statin use and the reduction of physical functions, was observed.ConclusionsStatin use was not associated with the decline of physical function in community-dwelling older Japanese adults. Geriatr Gerontol Int 2018; 18: 623-630.