Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
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DOI：
10.1016/j.amjcard.2008.09.085
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发表时间：
2009-02-01
影响因子：
2.8
通讯作者：
Jang, Ik-Kyung
中科院分区：
文献类型：
--
作者：
Chia, Stanley;Nagurney, John T.;Jang, Ik-Kyung
ST段抬高型心肌梗死时白细胞计数升高与不良临床结局相关直接经皮冠状动脉介入治疗（PCI）后白细胞计数的增加是否直接反映了较大的梗死面积和左心室损害尚不清楚。本研究的目的是评估白细胞和中性粒细胞计数与梗死面积和直接PCI术后左心室射血分数（LVEF）之间的关系。对来自MCC-135用于急性心肌梗死左心室挽救的评价（EVOLVE）研究的363例患者进行了评价，该研究是一项随机、双盲、安慰剂对照试验，旨在评估细胞内钙调节剂作为首次ST段抬高心肌梗死患者直接PCI辅助治疗的疗效。在PCI前和PCI后连续测量白细胞总数和分类计数。在5天和30天后使用单光子发射计算机断层扫描评估冠状动脉大小和LVEF，并对患者进行随访至180天。PCI术后24小时获得的总白细胞和中性粒细胞计数与梗死面积显著相关（r分别为0.34和0.37，p
Elevated leukocyte count during ST-segment elevation myocardial infarction is associated with adverse clinical outcomes. Whether increased leukocyte count after primary percutaneous coronary intervention (PCI) directly reflects larger infarct size and left ventricular impairment is not known. The aim of this study was to assess the relation between leukocyte and neutrophil counts with infarct size and the left ventricular ejection fraction (LVEF) after primary PCI. Three hundred sixty-three patients from the Evaluation of MCC-135 for Left Ventricular Salvage in Acute Myocardial Infarction (EVOLVE) study, a randomized, double-blind, placebo-controlled trial assessing the efficacy of intracellular calcium modulator as an adjunct to primary PCI in patients with first ST-segment elevation myocardial infarctions, were evaluated. Total and differential leukocyte counts were measured before and serially after PCI. Infarct size and the LVEF were assessed using single-photon emission computed tomography after 5 and 30 days, and patients were followed up to 180 days. Total leukocyte and neutrophil counts obtained 24 hours after PCI were significantly correlated with infarct size (r = 0.34 and 0.37, respectively, p