Plant cells synthesize glucose‐containing lipid‐linked oligosaccharides similar to those found in animals and yeast
Plant cells synthesize glucose‐containing lipid‐linked oligosaccharides similar to those found in animals and yeast
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植物细胞合成含葡萄糖的脂联寡糖，类似于动物和酵母中发现的寡糖
DOI：
10.1016/0014-5793(81)80020-8
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发表时间：
1981
期刊：
影响因子：
3.5
通讯作者：
L. Lehle
中科院分区：
文献类型：
--
作者：
L. Lehle
从一系列的研究中，已经变得明显的是，具有组成GlcsManpGlcNAcz[1]的含糖脂质结合寡糖似乎是膜结合蛋白以及分泌蛋白的天冬酰胺残基糖基化的直接供体。这种Glc-寡糖从脂质整体转移到新生多肽，随后加工产生聚甘露糖和复合寡糖链。有证据表明，葡萄糖可能在寡糖转移中具有信号功能[2，3]。到目前为止，在体内和体外描述“多萜醇途径”的研究主要使用动物[4-81]和酵母细胞[9-lo]。
From a series of studies it has become apparent that a glucosecontaining lipid-bound oligosaccharide with the composition GlcsManpGlcNAcz[l] seems to be the immediate donor in the glycosylation of asparagine residues of membrane-bound as well as secretory proteins. This Glc-oligosaccharide is transferred en bloc from the lipid to nascent polypeptides and subsequently processed giving rise to both polymannose and complex oligosaccharide chains. There is evidence that glucose could have a signal function in the oligosaccharide transfer [2, 3]. Studies delineating the ‘dolichol pathway’thus far, both in vivo and in vitro, have used mainly animal [4-81 and yeast cells [9-lo].