A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia.
A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia.
复制标题
一例肠道病毒性脑膜脑炎，表现为快速进展性痴呆。
DOI：
10.1038/ncpneuro0804
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发表时间：
2008
影响因子：
--
通讯作者：
VanderbiltContinuingMedicalEducationonline
中科院分区：
文献类型：
--
作者：
Valcour,Victor;Haman,Aissa;Cornes,Susannah;Lawall,Carson;Parsa,AndrewT;Glaser,Carol;Yagi,Shigeo;Tihan,Tarik;Bhatnagar,Julu;Geschwind,Michael;VanderbiltContinuingMedicalEducationonline
BackgroundA 70-year-old immunocompetent male presented to a memory disorders clinic with a 7-month illness that had begun with somatic complaints including transient right temporal head pain, left buttock pain, and right conjunctival injection. About 3 months after the first signs of illness, the patient had begun to develop insidious cognitive and behavioral decline, which progressed most rapidly in the 2 months before presentation. An assessment completed during hospitalization for intermittent fevers and confusion had not revealed an infectious etiology, although mild pleocytosis in the cerebrospinal fluid had been noted. Upon presentation to the memory disorders clinic, the patient was disoriented, distractible, laughed at inappropriate moments, and followed only one-step commands. He had hypophonic speech and had mildly increased axial tone. He scored 5 out of 30 on the Mini Mental State Examination and was admitted for expedited evaluation.InvestigationsPhysical examination, brain MRI, electroencephalogram, lumbar puncture, autoimmune and paraneoplastic testing, cerebral angiogram, cerebrospinal fluid analysis, enterovirus group-specific reverse transcriptase polymerase chain reaction assay, and RNA sequencing in brain biopsy samples.DiagnosisEnteroviral meningoencephalitis.ManagementIntravenous steroids with oral taper and intravenous immunoglobulin.
