Subcutaneous Panniculitis‐like T‐Cell Lymphoma in a 26‐Month‐Old Child with a Review of the Literature
Subcutaneous Panniculitis‐like T‐Cell Lymphoma in a 26‐Month‐Old Child with a Review of the Literature
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26 个月大儿童皮下脂膜炎样 T 细胞淋巴瘤文献综述
DOI：
10.1111/j.1525-1470.2006.00305.x
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发表时间：
2006
影响因子：
1.5
通讯作者：
Y. Park
中科院分区：
文献类型：
--
作者：
Jun Hee Yim;Mi;Hyung Ok Kim;B. Cho;N. Chung;Y. Park
摘要：皮下脂膜炎样T细胞淋巴瘤是一种罕见的皮肤细胞毒性T细胞淋巴瘤，优先浸润皮下组织。我们在这里报道了一名 26 个月大的韩国女孩身上发生的淋巴瘤。她的四肢和背部出现多发性红斑皮下结节，并伴有全身症状。她的皮下多发红斑结节病程持续了 1 个月，并且经常出现高烧。皮下结节的组织病理学结果是小叶性脂膜炎样物质，由非典型淋巴细胞和组织细胞组成。非典型淋巴细胞以花边状图案环绕单个脂肪细胞，一些组织细胞偶尔显示出吞噬白细胞的现象。免疫表型研究显示 CD3+、CD45RO+、CD20−、CD4−、CD8+ 和 CD56−。她目前正在接受环磷酰胺、阿霉素、长春新碱和泼尼松龙的联合化疗。
Abstract: Subcutaneous panniculitis‐like T‐cell lymphoma is a rare cytotoxic T‐cell lymphoma of the skin that preferentially infiltrates the subcutaneous tissue. We report here this lymphoma occurring in a 26‐month‐old Korean girl. She presented with multiple erythematous subcutaneous nodules on both extremities and her back along with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 1 month and a spiking fever was often noted. The histopathologic findings for the subcutaneous nodules were lobular panniculitis‐like material that was composed of atypical lymphocytes and histiocytes. The atypical lymphocytes characteristically rimmed individual fat cells in a lace‐like pattern and some of the histiocytes showed phagocytosed white blood cells occasionally. Immunophenotypic studies showed CD3+, CD45RO+, CD20−, CD4−, CD8+, and CD56−. She is currently being treated with combination chemotherapy of cyclophosphamide, doxorubicin, vincristine, and prednisolone.