Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
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DOI：
10.1042/bst0310415
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发表时间：
2003-04-01
影响因子：
3.9
通讯作者：
Ullman, B
中科院分区：
文献类型：
--
作者：
Heby, O;Roberts, SC;Ullman, B
Molecular, biochemical and genetic characterization of ornithine decarboxylase, S-adenosylmethionine decarboxylase and spermidine synthase establishes that these polyamine-biosynthetic enzymes are essential for growth and survival of the agents that cause African sleeping sickness, Chagas' disease, leishmaniasis and malaria. These enzymes exhibit features that differ significantly between the parasites and the human host. Therefore it is conceivable that exploitation of such differences can lead to the design of new inhibitors that will selectively kill the parasites while exerting minimal, or at least tolerable, effects on the parasite-infected patient.
