The Path of an Early Career Physician and Scientist in Cardiac Electrophysiology.
The Path of an Early Career Physician and Scientist in Cardiac Electrophysiology.
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心脏电生理学早期职业医师和科学家的道路。
DOI：
10.1161/circresaha.118.314016
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发表时间：
2018
影响因子：
20.1
通讯作者：
DeMazumder,Deeptankar
中科院分区：
文献类型：
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作者：
DeMazumder,Deeptankar
1270循环研究2018年12月7日和一个新的研究生课程国际愈合的艺术（http：//www. intmed. VCU。edu/inm/p-notes/PNAug031. pdf;导师：Richard P. Wenzel，MD）。这个项目是一项具有挑战性的工作，它教会了我在值得信赖的同事之间分担责任的价值，并形成机构间的合作，以实现更大的社会影响。我们在印度西孟加拉的农村地区度过了几个月，照顾贫困患者，获得有限的医疗保健，这对我来说是一次并将继续是一次令人谦卑的经历。在我的家庭工作人员培训期间，我继续引导我对学术心脏病学的好奇心。作为西奈山和埃尔姆赫斯特医院的实习生（2006-2007年;导师：约瑟夫·J·利伯，医学博士），我学会了如何在床边应用科学原理来加强病人护理，从领先的学者那里，比如瓦伦丁·福斯特博士在福斯特回合。作为弗吉尼亚大学的一名居民（主任：杰拉尔德W。Donowitz，医学博士），我参与了心律非线性动态分析的研究（2007-2009年;导师：J. Randall Moorman，医学博士和John P. DiMarco，医学博士，博士）。5随后，我加入了约翰霍普金斯大学，继续我的心脏病学临床研究（2009-2013;主任：Steven P. Schulman，MD）。与此同时，我从事基本的电生理学研究（导师：戈登F。Tomaselli，MD），6人参加了临床研究（导师：Steven R. Jones，MD），7并开发了一个新的转化项目，该项目最近已扩展为多中心前瞻性临床研究（CHAOS [Critical Health Assessment & Outcomes Study/Score]; https：//clinicaltrials. gov/ct 2/show/NCT 02766166），并计划进行干预性试验。随后，我继续从事心脏电生理学的临床研究8（2013-2015;导师：Hugh G. Calkins，MD）。当我加入Tomaselli博士的实验室（2011-2013）时，我立即被要求开发一个新项目。心脏起搏治疗（CRT）的项目资助最吸引我，因为这涉及到与大卫A博士的密切互动。卡斯和布莱恩·奥罗克是我见过的最杰出的科学家。我还记得有几次，我向卡斯博士提出一个科学问题，导致他在走廊里进行了几个小时的热情洋溢的讨论。我和奥罗克博士的经历很相似，尽管他们都有自己独特的风格。他们的研究小组对心力衰竭中β-肾上腺素能信号的重塑进行了开创性的研究，这种重塑被CRT逆转。我很感兴趣-了解CRT的工作原理可能会导致新的疗法利用相同的机制！因为β-肾上腺素能和胆碱能通路是紧密耦合的，一个通路的变化会影响另一个通路。胆碱能系统如何促进心力衰竭和CRT效应？这个问题推动了我在心脏病学研究的最后两年（2011-2013）的博士后研究。我们发现了一种新的机制，CRT差异重塑毒蕈碱受体，以改善心脏功能衰竭犬和人类的心脏。9.和大多数科学发现一样，我们的工作带来的问题多于答案。完成临床电生理学培训（2013-2015）后，我有意识地选择通过NIH NHLBI K99途径延长培训（2015-2016）（导师：Drs O 'Rourke，Kass，Tomaselli，Baumgarten和Mark E.安德森）。这支由导师组成的梦之队帮助我精通各种重叠的领域，在某些情况下，这些领域以前从未应用于心脏病学。其结果是，几乎根据定义，我准备进行研究，.
1270 Circulation Research December 7, 2018 and a new graduate course The Art of International Healing (http://www. intmed. vcu. edu/inm/p-notes/PNAug031. pdf; mentor: Richard P. Wenzel, MD). This project was a challenging undertaking that taught me the value of sharing responsibility among trusted colleagues and forming interinstitutional collaborations to achieve a much larger social impact. The months we spent in rural parts of West Bengal, India, caring for indigent patients with limited access to health care was and continues to be a humbling experience for me. During my housestaff training, I continued to channel my curiosity in academic cardiology. As an intern at the Mount Sinai and Elmhurst hospitals (2006–2007; mentor: Joseph J. Lieber, MD), I learned how to apply scientific principles at the bedside to enhance patient care from leading academicians, such as Dr Valentin Fuster during Fuster Rounds. As a resident at the University of Virginia (Director: Gerald W. Donowitz, MD), I participated in research on nonlinear dynamic analysis of cardiac rhythm (2007–2009; mentors: J. Randall Moorman, MD, and John P. DiMarco, MD, PhD). 5 Subsequently, I joined the Johns Hopkins University to pursue my clinical fellowship in cardiology (2009–2013; Director: Steven P. Schulman, MD). At the same time, I pursued basic electrophysiology research (mentor: Gordon F. Tomaselli, MD), 6 participated in clinical research (mentor: Steven R. Jones, MD), 7 and developed a new translational project, which has recently expanded into a multicenter prospective clinical study (CHAOS [Critical Health Assessment & Outcomes Study/Score]; https://clinicaltrials. gov/ct2/show/NCT02766166), with plans for an interventional trial. Subsequently, I pursued my clinical fellowship in cardiac electrophysiology8 (2013–2015; mentor: Hugh G. Calkins, MD). When I joined Dr Tomaselli’s lab (2011–2013), I was immediately charged with developing a new project. The program project grant on cardiac resynchronization therapy (CRT) appealed to me the most, as this involved close interactions with Drs David A. Kass and Brian O’Rourke—two of the most brilliant scientists I have met. I can recall several occasions when I engaged Dr Kass with a scientific question that led to hours of passionate and stimulating discussions in the hallway. My experiences with Dr O’Rourke were similar, although each had their own unique style. Their group had done groundbreaking work on remodeling of β-adrenergic signaling in heart failure that is reverse remodeled by CRT. I was intrigued—understanding how CRT works might lead to new therapies exploiting the same mechanism! Because β-adrenergic and cholinergic pathways are intimately coupled, changes in one should affect the other. How does the cholinergic system contribute to heart failure and CRT effects? This question drove my postdoctoral research during the last two years of my cardiology fellowship (2011–2013). We discovered a novel mechanism whereby CRT differentially remodels muscarinic receptors to improve cardiac function in failing canine and human hearts. 9 As with most scientific discoveries, our work led to more questions than answers. 10, 11 After completing my clinical electrophysiology training (2013–2015), I consciously chose to extend my training (2015–2016) via the NIH NHLBI K99 pathway (mentors: Drs O’Rourke, Kass, Tomaselli, Baumgarten, and Mark E. Anderson). This dream team of mentors helped me become well versed in a variety of overlapping fields that, in some cases, have not been applied to cardiology before. The result is that, almost by definition, I am primed to perform research that …