Role of complement in IgA nephropathy.
Role of complement in IgA nephropathy.
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DOI：
10.1007/s40620-015-0245-6
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发表时间：
2016-02
影响因子：
3.4
通讯作者：
van Kooten C
中科院分区：
文献类型：
--
作者：
Daha MR;van Kooten C
免疫球蛋白A肾病（IgAN）的特征是伊加在肾小球系膜中的沉积。已发现这种肾小球系膜伊加主要由聚合的IgA 1组成，其驱动肾小球系膜细胞的活化并导致几种炎症介质的过量产生。肾小球系膜细胞的激活被伊加激活补体系统的能力放大，最初认为主要通过补体的替代途径发生。然而，最近的研究表明，凝集素途径参与与肾脏疾病的进展有很强的关联。本文就补体在伊加介导的炎症过程中的作用作一综述.
Immunoglobulin A nephropathy (IgAN) is characterized by the deposition of IgA in the mesangium of glomeruli. This mesangial IgA has been found to consist mainly of polymeric IgA1 which drives the activation of the mesangial cells and results in excessive production of several inflammatory mediators. The activation of mesangial cells is amplified by the ability of IgA to activate the complement system, originally thought to occur mainly via the alternative pathway of complement. However more recent studies indicate that lectin pathway involvement has a strong association with progression of renal disease. In this review we summarize the contribution of complement to the IgA- mediated inflammatory process.