Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model
Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model
复制标题
使用斑马鱼鳞片再生模型研究抗骨质疏松药物对地塞米松诱导的骨质疏松样表型的影响
DOI：
10.1016/j.jphs.2020.02.011
复制
发表时间：
2020
影响因子：
3.5
通讯作者：
Hara Hideaki
中科院分区：
文献类型：
--
作者：
Saito Yuichi;Nakamura Shinsuke;Chinen Naoki;Shimazawa Masamitsu;Hara Hideaki
糖皮质激素性骨质疏松症（GIOP）有几种动物模型，但每种模型都需要较长的时间来评估药物效果。斑马鱼鳞片被归类为真皮骨，可能代表一种方便的GIOP动物模型，因为它们在去除后迅速再生。我们澄清了地塞米松处理的再生鳞片出现畸形，大小和圆形减小。抗骨质疏松药物挽救鳞片畸形表型8天后的鳞片去除。因此，地塞米松诱导的再生鳞片畸形模型可能是发现治疗GIOP药物的有用动物模型。
There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that dexamethasone-treated regenerating scales showed malformations, decreased size and circularity. Anti-osteoporosis drugs rescued the scale malformation phenotype eight-days following the removal of scales. Hence, the dexamethasone-induced regenerating scale malformation model may be a useful animal model for discovering drugs to treat GIOP.