IDIOPATHIC POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME - AN ATTENUATED FORM OF ACUTE PANDYSAUTONOMIA
IDIOPATHIC POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME - AN ATTENUATED FORM OF ACUTE PANDYSAUTONOMIA
复制标题
DOI：
10.1212/wnl.43.1_part_1.132
复制
发表时间：
1993-01-01
期刊：
影响因子：
9.9
通讯作者：
LOW, PA
中科院分区：
文献类型：
--
作者：
SCHONDORF, R;LOW, PA
为了描述特发性体位性心动过速综合征（POTS）的特征，我们回顾了所有年龄在20 ~ 51岁的患者的记录，这些患者在马约自主神经反射实验室就诊，并在休息或头高位倾斜时表现出心动过速。这些患者通常是发生持续性头晕和疲劳或胃肠动力障碍急性发作的女性。在7名患者中，病毒性疾病可能先于症状发作。在2例病例中，存在小纤维感觉神经病的体征和症状。自主神经功能的实验室评价显示舒张压升高至倾斜（5/16），Valsalva比率升高，Valsalva动作II相显著降低，IV相超调正常，强迫性呼吸性窦性心律失常正常。部分患者出现定量汗轴突反射试验和体温调节汗试验异常，以及直立位时儿茶酚胺水平过度升高。我们的结论是，在许多情况下，POTS可能是一种轻度急性自主神经病变的表现。
To characterize the idiopathic postural orthostatic tachycardia syndrome (POTS), we reviewed the records of all patients aged 20 to 51 who presented to the Mayo Autonomic Reflex Laboratory and who exhibited tachycardia at rest or during head-up tilt. These patients were usually women who experienced an acute onset of persistent lightheadedness and fatigue or gastrointestinal dysmotility. In seven patients, a viral illness may have preceded the onset of symptoms. In two instances, signs and symptoms of a small-fiber sensory neuropathy were present. Laboratory evaluation of autonomic function revealed increased diastolic blood pressure to tilt (5/16), increased Valsalva ratio, marked decrease in phase II of the Valsalva maneuver with normal phase IV overshoot, and normal forced respiratory sinus arrhythmia. Abnormal quantitative sudomotor axon reflex test and thermoregulatory sweat test and an excessive orthostatic increase of catecholamines were found in some patients. We conclude that in many instances POTS m be a manifestation of a mild form of acute autonomic neuropathy.