STRUCTURE OF TRABECULATED DETRUSOR SMOOTH-MUSCLE IN CASES OF PROSTATIC HYPERTROPHY
STRUCTURE OF TRABECULATED DETRUSOR SMOOTH-MUSCLE IN CASES OF PROSTATIC HYPERTROPHY
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DOI：
10.1159/000280347
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发表时间：
1980-01-01
影响因子：
1.6
通讯作者：
DIXON, JS
中科院分区：
文献类型：
--
作者：
GOSLING, JA;DIXON, JS
对前列腺肥大导致膀胱出口梗阻患者的小梁化膀胱活检标本的光镜和电镜结构与对照膀胱标本的形态进行比较。在后者中，逼尿肌肌束被比较为平滑肌细胞紧密地堆积在一起，很少有结缔组织介入。无论年龄大小，小梁化膀胱逼尿肌包含许多肌束，其中组成细胞直径相对较小，并被致密的结缔组织广泛分开。本研究中未获得平滑肌肥大或增生的形态学证据。在EM中，小梁化膀胱的平滑肌细胞之间的结缔组织包含，除了胶原纤维，电子致密的微纤维的广泛的网状结构显然与平滑肌细胞的基底层连续。平滑肌细胞之间的紧密接近区域不受小梁形成的影响，自主神经末梢的分布和精细结构也不受影响。这些观察结果旨在形成一个基线，用于与未来对不同病因引起的小梁形成的形态学研究结果进行比较。
The light microscopic and EM structure of biopsy samples of trabeculated urinary bladder from patients with proven outflow obstruction due to prostatic hypertrophy was compared with the morphology of control bladder specimens. In the latter, the detrusor muscle bundles were compared of smooth muscle cells closely packed together with very little intervening connective tissue. Irrespective of age, detrusor muscle from trabeculated bladders contained many muscle bundles in which the constituent cells were of relatively small diameter and were widely separated from each other by dense masses of connective tissue. No morphological evidence for smooth muscle hypertrophy or hyperplasia was obtained in the present study. In the EM, the connective tissue between the smooth muscle cells of trabeculated bladders contained, in addition to collagen fibrils, an extensive meshwork of electron-dense microfibrils apparently in continuity with the basal laminae of the smooth muscle cells. Regions of close approach between smooth muscle cells were unaffected by trabeculation as was the distribution and fine structure of autonomic nerve terminals. These observations are intended to form a baseline for comparison with the results of future morphological studies of trabeculation arising in response to different etiological factors.