Role of the medullary raphe nuclei in the respiratory response to CO2
Role of the medullary raphe nuclei in the respiratory response to CO2
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DOI：
10.1016/s0034-5687(97)00110-2
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Martin, RJ
中科院分区：
文献类型：
--
作者：
Dreshaj, IA;Haxhiu, MA;Martin, RJ
我们的特点是在延髓中线内的神经元的作用，膈神经和舌下神经的反应，高碳酸血症在早期发展。对去皮质或麻醉、迷走神经切断和机械通气的14-20日龄仔猪进行研究。可逆性撤回中线神经元的活动诱导微量注射利多卡因（2%，300 nl; n = 10）和病变引起的神经毒性剂，鹅膏蕈氨酸（n = 12），在相同的网站微量注射。在任何给定的呼气末CO2浓度下，利多卡因后膈神经和舌下神经的峰值活动均显著低于对照组（P < 0.01）。注射鹅膏蕈氨酸后1-2 h，膈神经和舌下神经对CO的反应均显著低于对照组（P < 0.01）。结果表明，第一次，延髓中线神经元所需的充分表达高碳酸血症的呼吸反应，并提高这些核的功能障碍可能有助于呼吸不稳定在出生后早期的生活。(C)1998年Elsevier Science B.V.
We characterized the role of neurons within the midline of the medulla oblongata on phrenic and hypoglossal nerve responses to hypercapnia during early development. Studies were performed on decorticate or anesthetized, vagotomized and mechanically ventilated 14-20 day old piglets. Reversible withdrawal of midline neuronal activity was induced by microinjections of lidocaine (2%, 300 nl; n = 10) and lesioning was caused by microinjections of the neurotoxic agent, ibotenic acid (n = 12), at the same sites. At any given end-tidal CO2, peak phrenic and hypoglossal activities after lidocaine were significantly lower than in the control period (P < 0.01). Similarly, 1-2 h after injections of ibotenic acid, both phrenic and hypoglossal nerve responses to CO, were significantly lower than in the control period (P < 0.01). The results indicate for the first time that the medullary midline neurons are required for full expression of ventilatory responses to hypercapnia and raise the possibility that dysfunction of these nuclei may contribute to respiratory instability during early postnatal life. (C) 1998 Elsevier Science B.V.