Epidemiology of idiopathic pulmonary fibrosis.
Epidemiology of idiopathic pulmonary fibrosis.
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DOI：
10.2147/clep.s54815
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发表时间：
2013-11-25
影响因子：
3.9
通讯作者：
Collard HR
中科院分区：
文献类型：
--
作者：
Ley B;Collard HR
特发性肺纤维化是一种原因不明的慢性肺纤维化，发生于成人，预后不良。由于其在诊断和编码实践中的罕见和进化，其流行病学一直很难研究。虽然不常见，但在其发生(即发病率、流行率)和对公共健康的影响(即卫生保健成本和资源利用)方面可能都被低估了。发病率和死亡率似乎在上升，预计患病率将随着人口老龄化而增加。潜在的危险因素包括职业和环境暴露、吸烟、胃食道反流和遗传因素。准确了解其流行病学是重要的，特别是在新的治疗方法出现的情况下。
Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of unknown cause that occurs in adults and has a poor prognosis. Its epidemiology has been difficult to study because of its rarity and evolution in diagnostic and coding practices. Though uncommon, it is likely underappreciated both in terms of its occurrence (ie, incidence, prevalence) and public health impact (ie, health care costs and resource utilization). Incidence and mortality appear to be on the rise, and prevalence is expected to increase with the aging population. Potential risk factors include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors. An accurate understanding of its epidemiology is important, especially as novel therapies are emerging.