Levels of expression of P-selectin, E-selectin, and intercellular adhesion molecule-1 in coronary atherectomy specimens from patients with stable and unstable angina pectoris.
Levels of expression of P-selectin, E-selectin, and intercellular adhesion molecule-1 in coronary atherectomy specimens from patients with stable and unstable angina pectoris.
复制标题
稳定型和不稳定型心绞痛患者冠状动脉粥样斑块切除标本中 P-选择素、E-选择素和细胞间粘附分子-1 的表达水平。
DOI：
10.1016/s0002-9149(96)00861-2
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Lefer,DJ
中科院分区：
文献类型：
--
作者：
Tenaglia,AN;Buda,AJ;Wilkins,RG;Barron,MK;Jeffords,PR;Vo,K;Jordan,MO;Kusnick,BA;Lefer,DJ
不稳定型心绞痛发生在动脉粥样硬化斑块破裂时。最近的证据表明炎症在这个过程中的作用。白细胞-内皮细胞相互作用在炎症中是重要的，并且由细胞粘附分子调节。本研究旨在检测不稳定型心绞痛患者血管细胞粘附分子和细胞因子的表达。在不稳定型和稳定型心绞痛患者中进行定向冠状动脉粥样硬化斑块切除术。用免疫组织化学方法检测细胞粘附分子P-选择素、E-选择素和细胞间粘附分子-1在所获得的组织中的表达。此外，还检测了参与细胞粘附分子表达调节的细胞因子肿瘤坏死因子-α和白细胞介素-1 β的表达。不稳定型心绞痛患者的动脉粥样硬化切除标本中P-选择素表达显著高于稳定型心绞痛患者。P-选择素主要在内皮细胞上表达。不稳定型心绞痛和稳定型心绞痛患者的其他因素无差异。此外，其他临床和血管造影变量与任何细胞粘附分子或细胞因子的差异表达无关。这些结果表明，P-选择素在不稳定型心绞痛的过程中可能发挥作用。采用免疫组织化学方法检测定向冠状动脉粥样硬化斑块切除术标本中细胞粘附分子P-选择素、E-选择素和细胞间粘附分子-1的表达。动脉粥样硬化切除标本显示不稳定型心绞痛患者的P-选择素表达显著高于稳定型心绞痛患者。P-选择素主要表达在内皮细胞上，不稳定型心绞痛和稳定型心绞痛患者之间的其他因子的表达没有差异;结果表明P-选择素在不稳定型心绞痛的过程中可能起作用。
Unstable angina occurs when atherosclerotic plaque ruptures. Recent evidence suggests a role for inflammation in this process. Leukocyte-endothelial cell interactions are important in inflammation and are regulated by cell adhesion molecules. This study was designed to examine the vascular expression of cell adhesion molecules and cytokines in patients with unstable angina. Directional coronary atherectomy was performed in patients with unstable and stable angina. Expression of the cell adhesion molecules P-selectin, E-selectin, and intercellular adhesion molecule-1 in the tissue obtained was examined using immunohistochemistry. In addition, expression of the cytokines tumor necrosis factor-α and interleukin-1β, which participate in the regulation of cell adhesion molecule expression, was also examined. Atherectomy specimens had significantly greater P-selectin expression from patients with unstable angina than from patients with stable angina. P-selectin expression was observed primarily on endothelial cells. There were no differences in any of the other factors between patients with unstable and stable angina. In addition, other clinical and angiographic variables were not associated with differential expression of any of the cell adhesion molecules or cytokines. These results indicate a possible role for P-selectin in the process of unstable angina. Expression of the cell adhesion molecules P-selectin, E-selectin, and intercellular adhesion molecule-1 in specimens obtained by directional coronary atherectomy was examined using immunohistochemistry. Atherectomy specimens revealed significantly greater P-selectin expression from patients with unstable angina than from patients with stable angina. P-selectin expression was observed primarily on endothelial cells, and there were no differences in expression of the other factors between patients with unstable angina and stable angina; results indicate a possible role for P-selectin in the process of unstable angina.