Efficacy and safety of intense pulsed light in the treatment of inflammatory acne vulgaris with a novel filter
Efficacy and safety of intense pulsed light in the treatment of inflammatory acne vulgaris with a novel filter
复制标题
新型滤光片强脉冲光治疗炎性寻常痤疮的疗效和安全性
DOI：
10.1080/14764172.2019.1605450
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发表时间：
2019-04-28
影响因子：
1.2
通讯作者：
Du, Juan
中科院分区：
文献类型：
--
作者：
Chen, Sunyi;Wang, Yan;Du, Juan
摘要痤疮是一种常见的皮肤病，影响年轻人。强脉冲光（IPL）已成为治疗寻常痤疮的公认方法。我们的目的是评价一种新型强脉冲光滤光片在400-600 nm和800- 1200 nm波长下治疗炎症性痤疮病变的临床疗效和安全性。本前瞻性临床研究入组了2017年7月至2018年1月期间患有Pillsbury I-III型面部寻常痤疮的21例患者。以4周的间隔对受试者进行5次强脉冲光治疗。最终评估在最终治疗后1个月进行。治疗后1个月，超过75%的受试者表现出优良反应。Pillsbury Ⅰ ~ Ⅱ级患者有效率达88.24%。炎性病变显著减少（25.23 ± 2.76 vs 14.01 ± 1.98），具有统计学显著性（P = 0.031）。根据Hayashi对痤疮严重程度的评估，随访时有显著改善（P = 0.022）。此外，患者报告自我评价有显着改善。波长为400-600 nm和800- 1，200 nm的新型IPL滤光片为治疗炎性痤疮病变提供了有效的选择，特别是对于Pillsbury I-II型痤疮患者，具有最小的可逆副作用，例如短暂的炎症后色素沉着。
ABSTRACT Acne vulgaris is one of the most common skin diseases affecting young people. Intense pulsed light (IPL) has become a well-recognized method in the treatment of acne vulgaris. We aim evaluate the clinical efficacy and safety of a novel IPL filter at wavelength of 400–600 nm and 800–1,200 nm in the treatment of inflammatory acne lesions. Twenty-one patients with Pillsbury I–III facial acne vulgaris between July 2017 and January 2018 were enrolled in this prospective clinical study. Five sessions of IPL treatment were administered to the subjects at 4-week interval. Final assessment was performed 1 month after the final treatment. One month posttreatment, over 75% subjects exhibited excellent or good response. Of the Pillsbury I–II patients, the effective rate reached 88.24%. The inflammatory lesions were dramatically decreased (25.23 ± 2.76 versus 14.01 ± 1.98) and statistically evident (P = .031). According to Hayashi assessment of acne severity, there was a significant improvement at follow-up visit (P = .022). Moreover, patients reported significant improvements in self-evaluation. The novel IPL filter at wavelength of 400–600 nm and 800–1,200 nm provides an effective option to treatment of inflammatory acne lesions, especially for Pillsbury I–II acne patients, with minimal reversible side effects, such as transient post-inflammatory pigmentation.