Bone mineral density in patients with treated Addison's disease
Bone mineral density in patients with treated Addison's disease
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DOI：
10.1007/s001980050251
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发表时间：
1999-01-01
影响因子：
4
通讯作者：
Reid, IR
中科院分区：
文献类型：
--
作者：
Braatvedt, GD;Joyce, M;Reid, IR
一些研究报道了阿狄森氏病患者的骨密度（BMD）低，而另一些研究发现BMD正常。皮质类固醇的过度替代和肾上腺雄激素缺乏可能导致这些患者的BMD降低。本研究的目的是使用双能X线骨密度测定法检查多个骨骼部位接受治疗的Addison病患者的BMD，并研究这些测量值与皮质类固醇剂量之间的关系。19名男性，3名绝经前和7名绝经后女性阿狄森病进行了研究，并从这些患者的数据进行了分析，单独和作为一个组。男性的平均SEM年龄和Addison病持续时间分别为44 +/- 3.8年和15 +/- 2.2年，绝经前女性为40 +/- 2年和5 +/- 2.4年，绝经后女性为68 +/- 4年和20 +/- 5年。8名男性意外性腺功能减退（血清睾酮
Some studies have reported low bone mineral density (BMD) in patients with Addison's disease, whereas others have found BMD to be normal. It is possible that over-replacement of corticosteroids and adrenal androgen deficiency may contribute to a reduction in BMD in these patients. The aims of this study were to examine BMD using dual-energy X-ray absorptiometry in patients with treated Addison's disease at multiple skeletal sites and to investigate the relationships between these measurements and corticosteroid dose. Nineteen men, 3 premenopausal and 7 postmenopausal women with Addison's disease were studied and data from these patients were analyzed separately and as a group. The mean SEM age and duration of Addison's disease of the men were 44 +/- 3.8 years and 15 +/- 2.2 years, in the premenopausal women 40 +/- 2 years and 5 +/- 2.4 years, and in the postmenopausal women 68 +/- 4 years and 20 +/- 5 years, respectively. Eight men were unexpectedly hypogonadal (serum testosterone