Viral manipulation of the host immune response.
Viral manipulation of the host immune response.
复制标题
病毒操纵宿主免疫反应。
DOI：
10.1016/j.coi.2015.06.012
复制
发表时间：
2015-10
影响因子：
7
通讯作者：
Spencer JV
中科院分区：
文献类型：
--
作者：
Christiaansen A;Varga SM;Spencer JV
病毒是专性细胞内寄生虫，需要宿主作为基本机制来复制并最终传播到新的易感宿主。与此同时，免疫系统已经进化到保护人体免受病毒和其他病原体的入侵。为了应对这一点，病毒已经开发了一系列策略，不仅可以避免免疫检测，而且可以主动操纵宿主免疫反应，以创造更有利于感染的环境。在这里，我们描述了最近的进展，揭示了新的机制，病毒通过调节细胞因子和趋化因子信号网络，干扰抗原呈递和T细胞反应，并防止抗体产生扭曲宿主的免疫反应。
Viruses are obligate intracellular parasites that require a host for essential machinery to replicate and ultimately be transmitted to new susceptible hosts. At the same time, the immune system has evolved to protect the human body from invasion by viruses and other pathogens. To counter this, viruses have developed an arsenal of strategies to not only avoid immune detection but to actively manipulate host immune responses to create an environment more favorable for infection. Here, we describe recent advances uncovering novel mechanisms by which viruses skew host immune responses through modulation of cytokine and chemokine signaling networks, interference with antigen presentation and T cell responses, and preventing antibody production.