Emerging Co-signaling Networks in T Cell Immune Regulation.
Emerging Co-signaling Networks in T Cell Immune Regulation.
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T细胞免疫调节中的新兴共同信号网络。
DOI：
10.4110/in.2013.13.5.184
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发表时间：
2013-10
期刊：
影响因子：
6
通讯作者：
Choi I
中科院分区：
文献类型：
--
作者：
Jung K;Choi I
共信号分子是表面糖蛋白，可正向或负向调节 T 细胞对抗原的反应。共信号配体和受体在抗原呈递细胞 (APC) 和 T 细胞表面之间串扰，并调节 T 细胞受体 (TCR) 信号传导的最终强度和质量。在过去的十年中，通过对新发现的共信号分子主导的免疫调节的潜在机制的理解，以及针对称为免疫检查点的共抑制分子在治疗自身免疫性疾病和癌症方面的成功的临床前和临床试验，共信号研究领域取得了进步。在这篇综述中，我们简要描述了著名的 B7 协同信号家族成员在表达、功能和治疗意义方面的特征，并介绍了新发现的 B7 成员，如 B7-H5、B7-H6 和 B7-H7。
Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.