Data on combination effect of PEG-coated gold nanoparticles and non-thermal plasma inhibit growth of solid tumors.
Data on combination effect of PEG-coated gold nanoparticles and non-thermal plasma inhibit growth of solid tumors.
复制标题
DOI：
10.1016/j.dib.2016.08.059
复制
发表时间：
2016-12
期刊：
影响因子：
1.2
通讯作者：
Choi EH
中科院分区：
文献类型：
--
作者：
Kaushik NK;Kaushik N;Yoo KC;Uddin N;Kim JS;Lee SJ;Choi EH
高耐药的肿瘤细胞在低剂量的血浆下很难治疗。因此，等离子体治疗增强剂的开发越来越受到研究人员的关注。某些增强剂可以提高等离子体对肿瘤细胞损伤的选择性。在这个数据集中，我们报告了低剂量的聚乙二醇包覆金纳米颗粒的应用，并添加了等离子体处理。该数据包括聚乙二醇包被的GNP和冷等离子体对两种实体瘤细胞系T98G胶质母细胞瘤和A549肺腺癌的影响。报告了通过这种联合治疗进行的细胞增殖、肿瘤干细胞群体频率的研究。最后，我们利用裸鼠移植瘤模型，在此数据集中包括了体内联合治疗的效果。本文中提供的数据支持随附的出版物“低剂量的聚乙二醇包覆金纳米颗粒通过阻断PI3K/AKT驱动的信号轴，从而通过抑制生长和EMT来抑制细胞转化，从而使实体瘤对冷血浆敏感”(N.K.Kaushik，N.Kaushik，K.C.Yoo，N Uddin，J.S.Kim，S.J.Lee等，2016)。
Highly resistant tumor cells are hard to treat at low doses of plasma. Therefore, researchers have gained more attention to development of enhancers for plasma therapy. Some enhancers could improve the efficacy of plasma towards selectivity of cancer cells damage. In this dataset, we report the application of low doses of PEG-coated gold nanoparticles with addition of plasma treatment. This data consists of the effect of PEG-coated GNP and cold plasma on two solid tumor cell lines T98G glioblastoma and A549 lung adenocarcinoma. Cell proliferation, frequency of cancer stem cell population studies by this co-treatment was reported. Finally, we included in this dataset the effect of co-treatment in vivo, using tumor xenograft nude mice models. The data supplied in this article supports the accompanying publication “Low doses of PEG-coated gold nanoparticles sensitize solid tumors to cold plasma by blocking the PI3K/AKT-driven signaling axis to suppress cellular transformation by inhibiting growth and EMT” (N. K. Kaushik, N. Kaushik, K. C. Yoo, N Uddin, J. S. Kim, S. J. Lee et al., 2016).