A simple clinical colitis activity index
A simple clinical colitis activity index
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DOI：
10.1136/gut.43.1.29
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发表时间：
1998-07-01
期刊：
影响因子：
24.5
通讯作者：
Allan, RN
中科院分区：
文献类型：
--
作者：
Walmsley, RS;Ayres, RCS;Allan, RN
溃疡性结肠炎患者的适当药物治疗主要取决于症状的严重程度。医院对疾病活动严重程度的评估包括实验室指标的调查和粘膜炎症的乙状结肠镜评估，目的是建立一个简化的临床结肠炎活动指数，以帮助对结肠炎急性加重的初步评估。最初在63例溃疡性结肠炎患者的疾病活动性评估中评价了简单指数的发展信息，其中使用Powell-Tuck指数（包括症状、体征和乙状结肠镜外观）。然后，通过与利用临床和实验室数据以及疾病严重程度的五个血液学和生化标志物的复杂指数进行比较，在不同组患者的113个评估中进一步评估新指数。结果-新设计的简单临床结肠炎活动指数，由五个临床标准的分数组成，显示出与Powell-Tuck指数的高度显著相关性（r=0.959，p
Background-The appropriate medical treatment of patients with ulcerative colitis is determined largely by the severity of symptoms. Hospital assessment of the severity of disease activity includes investigation of laboratory indices and sigmoidoscopic assessment of mucosal inflammation.Aims-To develop a simplified clinical colitis activity index to aid in the initial evaluation of exacerbations of colitis.Methods-The information for development of the simple index was initially evaluated in 63 assessments of disease activity in patients with ulcerative colitis where disease activity was evaluated using the Powell-Tuck Index (which includes symptoms, physical signs, and sigmoidoscopic appearance). The new index was then further evaluated in 113 assessments in a different group of patients, by comparison with a complex index utilising clinical and laboratory data, as well as five haematological and biochemical markers of disease severity.Results-The newly devised Simple Clinical Colitis Activity Index, consisting of scores for five clinical criteria, showed a highly significant correlation with the Powell-Tuck Index (r=0.959, p