Incorporation of [U-13C]glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2)
Incorporation of [U-13C]glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2)
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DOI：
10.1039/b101615f
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发表时间：
2001-01-01
影响因子：
4.9
通讯作者：
Chater, KF
中科院分区：
文献类型：
--
作者：
Challis, GL;Chater, KF
在天蓝色链霉菌中观察到[U-C-13]甘油整合到线性质粒编码的次级代谢产物亚甲基霉素A中，无论是完整的还是通过代谢为乙酰辅酶A间接的，这表明这种不寻常的抗生素可能的早期生物合成步骤。
Incorporation of [U-C-13]glycerol into the linear plasmid-encoded secondary metabolite methylenomycin A, both intact and indirectly via metabolism to acetyl CoA, was observed in Streptomyces coelicolor suggesting plausible early biosynthetic steps for this unusual antibiotic.