TRANSGENIC MODELS OF TUMOR-DEVELOPMENT
TRANSGENIC MODELS OF TUMOR-DEVELOPMENT
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DOI：
10.1126/science.1957168
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发表时间：
1991-11-22
期刊：
影响因子：
56.9
通讯作者：
CORY, S
中科院分区：
文献类型：
--
作者：
ADAMS, JM;CORY, S
通过将候选促肿瘤基因引入受精卵，已经创造了许多易患癌症的小鼠品系。每个转基因株都倾向于发展特定类型的肿瘤，但它们通常是随机出现的，因为需要与引入的癌基因合作的基因的自发突变。这些小鼠提供了对单个癌基因对细胞增殖、分化和活力以及癌基因协同性的影响的见解。它们的易感状态使它们对病毒和化学致癌作用敏感，这些小鼠应该在潜在致癌物、治疗和预防措施的测试中证明是有价值的。
Numerous cancer-prone strains of mice have been created by the introduction of candidate tumor-promoting genes into fertilized eggs. Each transgenic strain is predisposed to develop specific types of tumors, but they usually arise stochastically because of the need for spontaneous mutation of genes that collaborate with the introduced oncogene. These mice are providing insights into the effects of individual oncogenes on cellular proliferation, differentiation, and viability, as well as on oncogene cooperativity. Their predisposed state imposes sensitivity to viral and chemical carcinogenesis, and the mice should prove valuable in tests of potential carcinogens, therapies, and preventive measures.